Diagnostic Value of Endocervical Curettage Under Colposcope in Women With HPV 16/18 Infection
Objective Analyze the diagnostic value of endocervical curettage under colposcope in women infected with human papilloma virus(HPV)16/18.Methods A total of 150 women who received HPV screening combined with thinprep cytology test(TCT)at department of obstetrics and gynecology clinic,Nan'an Maternal and Child Health Hospital from January 2021 to December 2022 were selected,and colposcopy was performed within the following 3 months.The diagnostic value of endocervical curettage under colposcope were analyzed.Results Two cases of high grade squamous intraepithelial lesions and the above lesions(HSIL+)were detected during endocervical curettage under colposcope,that is,the additional detection rate of HSIL+ for endocervical curettage under colposcope was 1.33%(2/150).The final pathological examination confirmed that 34 patients had HSIL+.The total positive rate of endocervical curettage under colposcope was 6.67%(10/150).The sensitivity of endocervical curettage under colposcope for HSIL+ lesions was 29.41%(10/34).The results of binary logistic regression analysis showed that age,cytology(ASC-H/HSIL+),complete invisibility of transformation area,and hrHPV infection(+)were independent influencing factors for the detection rate of HSIL+ after cervical scraping surgery(P<0.05).HPV 16/18 infection is an independent risk factor for the positive rate of endocervical curettage under colposcope(P<0.05).Endocervical curettage under colposcope has high diagnostic value in patients with atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion(ASC-H)/HSIL+,age≥30 years old,and HPV 16/18 infection in all age groups,with a clinical diagnosis of 11.0%-44.4%.The positive rate of endocervical curettage under colposcope is relatively low in individuals with mild cytological abnormalities[aypical squamous cells of undetemined significance(ASCUS)/low-grade squamous intraepithelial lesions(LSIL)]and high risk human papilloma virus(hrHPV)infections other than 16/18 in various age groups.Conclusion If a woman experiences HPV16/18 infection and is≥30 years old,or if her cytological test results are ASC-H/HSIL,choosing endocervical curettage under colposcope for diagnosis has high value.If there are only slight abnormalities in the cytological examination results of women,endocervical curettage under colposcope cannot achieve satisfactory diagnostic value.The research results of this article provide reference content for the formulation of standards for the later stage of endocervical curettage under colposcope.
human papilloma virusinfectionendocervical curettagecolposcopycytologycervical liquid-based thin-layer cytology
万方数据
维普
