Clinical Effect of Gabapentin Combined With Short-Term Nerve Electrical Stimulation in the Treatment of Herpes Zoster-Associated Nerualgia of Head and Face
Objective To observe the efficacy and safety of gabapentin combined with short-term nerve electrical stimulation in the treatment of herpes zoster-associated neuralgia of head and face.Methods A total of 70 patients with acute or subacute herpes zoster-associated neuralgia admitted to the Sixth Affiliated Hospital of Guangzhou Medical University from August 2019 to January 2023 were selected as the study objects and randomly divided into control group and observation group,with 35 cases in each group.The control group was given gabapentin treatment,and the observation group was given the same dose of gabapentin combined with short-term nerve electrical stimulation for 4 weeks.Visual analogue scale(VAS),sleep quality score,and adverse reactions were compared before treatment(T0)and 1 week(T1),2 weeks(T2),4 weeks(T3),2 months(T4),3 months(T5),and 6 months(T6)after treatment to evaluate the clinical efficacy of patients.Results VAS scores of the 2 groups at different time points after treatment were lower than those before treatment(P<0.001).VAS scores of the observation group were lower than those of the control group at different time points after treatment,and the difference was statistically significant(P<0.05).The score of sleep quality in 2 groups at different time points after treatment was higher than that before treatment(P<0.001).The sleep quality score of the observation group was higher than that of the control group at the same time points after treatment,but the difference was not statistically significant(P>0.05).The total incidence of adverse reactions was 28.57%(10/35)in control group and 5.71%(2/35)in observation group,and the difference was statistically significant(P<0.05).Conclusion Gabapentin combined with short-term nerve electrical stimulation in the treatment of herpes zoster-associated neuralgia of head and face can reduce the pain degree of patients,improve sleep quality and have high safety,and the overall effect is better.
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