Discussion on the Therapeutic Effect of Helical Tomotherapy and Hybrid Intensity Modulated Radio-Therapy in Breast Cancer Patients
Objective To investigate the effects of helical tomotherapy TomoHelical and hybrid intensity modulated radio-therapy(Hy-IMRT)on early breast cancer patients undergoing breast conserving surgery.Methods A total of 50 patients with early breast cancer in department of radiation oncology,the First Affiliated Hospital of Xiamen University from January to July 2023 were selected and they were divided into TOMO group and Hy-IMRT group,25 cases in each group.The dosimetric parameters of the planning target volume(PTV),the dosimetry of the normal organs after radiotherapy and the difference of the immune function before and after radiotherapy were compared,the patients were followed up for 3 months and their prognosis was compared.Results Compared with Hy-IMRT,the PTV compliance index(CI)of TOMO treatment was(0.68±0.15),and the uniformity index(HI)was(1.09±0.12).The PTV compliance index(CI)of Hy-IMRT treatment was(0.54±0.12),and the uniformity index(HI)was(1.37±0.17),the differences were statistically significant(P<0.05).The mean dose(Dmean)of the entire lung in the TOMO group was(517.23±109.33)cGy,the volume percentage(volume5,V5)of the entire lung receiving a radiation dose of 5 Gy or more was(18.53±4.07)%,and the volume percentage(volume20,V20)of the entire lung receiving a radiation dose of 20 Gy or more was(10.55±2.83)%.The mean dose(Dmean)of the entire lung in the Hy-IMRT group was(581.12±113.72)cGy,the volume percentage(volume5,V5)of the whole lung receiving a radiation dose of 5 gray or more was(21.44±4.85)%,and the volume percentage(volume20,V20)of the whole lung receiving a radiation dose of 20 gray or more was(12.66±3.15)%.The TOMO group was lower than the Hy-IMRT group(P<0.05).The cardiac Dmean of the TOMO group was(521.44±86.72)cGy,the cardiac Dmean of the Hy-IMRT group was(577.14±96.33)cGy,the TOMO group was lower than the Hy-IMRT group(P<0.05).Conclusion The application of Tomo in early breast cancer patients undergoing breast-conserving surgery can effectively improve the uniformity of the dose distribution in the tumor target area and cause less damage to the surrounding normal tissues and organs,but more clinical data are needed.
breast-conserving surgery patientshelical tomographic radiotherapyhybrid intensity modulated radio-therapycoincidence indexhomogeneity indexorgans at risk
万方数据
维普
