Relationship Between Testosterone,PRL and Cognitive Function,Aggressive Behavior in Male Schizophrenic Patients
Objective To investigate the relationship between the levels of testosterone,prolactin(PRL)and cognitive function,aggressive behavior in male schizophrenia patients.Methods A total of 80 male patients with schizophrenia who were admitted to Xiamen Xianyue Hospital from October 2020 to October 2022 were studied.Detected all patients'testosterone,PRL,cognitive function[Montreal cognitive assessment scale(MOCA)]and aggression[modified overt aggression scale(MOAS)].The levels of serum testosterone and PRL in patients with different cognitive function and aggressive behavior were compared.The correlation between the detection results was analyzed.Results According to the total score of MOCA,patients were divided into the cognitive impairment group(MOCA<26 points,n=54)and the normal cognitive group(MOCA≥26 points,n=26).According to the total score of MOAS,patients were divided into the aggressive behavior group(MOAS≥5 points,n=31)and the non-aggressive behavior group(MOAS<5 points,n=49).The levels of testosterone and PRL in the cognitive impairment group were higher than those in the normal cognitive group,the differences were statistically significant(P<0.05).The levels of testosterone and PRL in the aggressive behavior group were higher than those in the non-aggressive behavior group,the differences were statistically significant(P<0.05).There was a negative correlation between testosterone level and the total score of MOCA in male schizophrenia patients(P<0.05),and a positive correlation between testosterone levels and total MOAS scores in male schizophrenia patients(P<0.05).The PRL level in male patients with schizophrenia was negatively correlated with the total score of MOCA(P<0.05),while the PRL level in male patients with schizophrenia was positively correlated with the total score of MOAS(P<0.05).Conclusion There is a certain correlation between testosterone,PRL levels and their cognitive impairment,aggressive behavior in male patients with schizophrenia.
male schizophreniatestosteroneprolactincognitive functionaggressive behaviorcorrelation analysis
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维普
