Study on the Value of Pharmacologic Intervention With Antibiotics for Surgical Prophylaxis of ClassⅠ Incision in Orthopedics
Objective To analyze the role and value of pharmaceutical intervention in prophylactic use of antibiotics in patients undergoing typeⅠ incision surgery.Methods A total of 800 patients were randomly selected from the department of orthopedics of Fujian Province Fuding Hospital during January to December 2021 as the study object.According to the intervention time,400 patients from January to June were classified into the control group,and 400 patients from July to December were classified into the observation group.The control group was given routine intervention,and the observation group was given pharmaceutical intervention.Indicators such as prophylactic antibiotic application rate,rational drug application rate,drug duration and timing,and drug type of patients in different groups were compared.Results Among the 400 patients in the control group,229 cases were prophylactic antibiotics,the drug application rate was 57.25%.Among the 400 patients in the observation group,212 patients were treated with prophylactic antibiotics,the drug application rate was 53.00%,and there was no significant difference in the rate of prophylactic antibiotics application among groups(P>0.05).The rational rate of treatment course of antibiotics in observation group was higher than that in control group,the difference was tatistically significant(P<0.05).However,there was no significant difference between the two groups in rational timing and rational choice of medication(P>0.05).The drug administration rate in the observation group was higher than that in the control group within 24 h after surgery,the difference was statistically significant(P<0.05),and the drug administration rate in the observation group≥24 to 48 h after surgery and 48 h after surgery was lower than that in the control group,the difference was statistically significant(P<0.05).At the same time,there was no statistical significance in the preoperative≥30 to 60 min administration rate,the preoperative>60 min administration rate and the postoperative<30 min administration rate between the two group,the difference was tatistically significant(P>0.05).The application types of prophylactic antibiotics in the two groups were concentrated in the first-generation cephalosporins,mainly cefazolin.There was no statistical significance in the application rates of the first-generation and second-generation cephalosporins and lincoamides between the two groups(P>0.05).Conclusion Pharmaceutical intervention in prophylactic use of antibiotics in orthopaedic patients undergoing typeⅠ incision surgery plays an important role in improving the rational application rate of antibiotics,so it is worth promoting in clinical practice.
orthopedic patientstypeⅠ incision surgeryprophylactic drugsantimicrobial drugspharmaceutical interventionrationality of medication
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