The Mechanism Investigation of Inhibitory Effect of Curcumin Targeting Muscle Fat Infiltration in Giant Rotator Cuff Tear
Objective To explore the inhibitory effect and mechanism of curcumin targeting the nucleotide-binding domain and leucine-rich repeat protein 3(NLRP3)/recombinant human interleukin-1β(IL-1β)inflammatory pathway on muscle adipose infiltration in cases of massive rotator cuff tear based on the traditional oriental medicine-foreign medicine principle.Methods Thirty models of chronic giant rotator cuff tear in rat shoulder joint were constructed,and 30 rat models were divided into three groups according to the dose of curcumin,namely the general diet group,the curcumin mixed low dose group and the curcumin mixed high dose group,with 10 rat models in each group.After pharmacological intervention in 30 rat models of chronic giant rotator cuff tear in the shoulder,Obtaining decalcified tissue sections of the shoulder fixation at weeks 2,3,and 4 in three rat models,the degree of fat immersion was measured in three rat models,NLRP3 and IL-1β indicators in muscle fat infiltration in giant rotator cuff tears were tested,to investigate the inhibitory effect of curcumin on muscle fat infiltration in giant rotator cuff tears.Results Compared to the normal diet group,both the low-dose and high-dose curcumin mixed diet groups showed a significant decrease in the levels of inflammatory factors,with the high-dose curcumin group exhibiting a more prominent reduction,the differences were statistically significant(P<0.05).Conclusion Based on the traditional oriental medicine-foreign medicine principle,the treatment of massive rotator cuff tear with curcumin can effectively intervene in the adipose infiltration of the disease.This is mainly due to the ability of curcumin to effectively inhibit the NLRP3 inflammasome,reduce IL-1β production,and alleviate skeletal muscle inflammatory damage.By inhibiting the NLRP3/IL-1β inflammatory pathway,curcumin can also suppress the adipogenic differentiation of skeletal muscle stem cells and reduce muscle adipose infiltration during the chronic process,thereby improving the biological vitality of the rotator cuff tendons and muscles.
traditional oriental medicine-foreign medicine principlecurcuminNLRP3/IL-1β inflammatory pathwaymuscle adipose infiltration in massive rotator cuff tearinflammasome inflammatory factorrotator cuff tendon muscle
万方数据
维普
