Nursing Effect of Benzalkonium Chloride Gargle on Chemotherapy Related Oral Fungal Infection and Its Influence on Quality of Life
Objective To explore the nursing effect of benzalkonium chloride gargle on chemotherapy related oral fungal infection and the impact of quality of life.Methods A total of 147 hematological patients in the Second Affiliated Hospital of Fujian Medical University who underwent chemotherapy and developed chemotherapy related oral fungal infection from January 2020 to March 2023 were selected as the study subjects.They were randomly divided into the control group(73 cases)and the observation group(74 cases)using a random number table method.The patients in the control group were given gargle nursing care of nystatin solution,and the patients in the observation group were given 0.01%benzalkonium chloride gargle on the basis of the nystatin solution gargle.The differences in nursing effect,quality of life,treatment satisfaction and incidence of adverse reactions between the two groups were compared.Results The effective rate of the observation group was 85.14%(63/74),while the effective rate of the control group was 72.60%(53/73),the difference was statistically significant(χ2=6.340,P=0.042).The quality-of-life scores of pain/discomforts,anxiety/depression and overall state in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).The scores of action ability,self-care and daily activities were similar to the control group,the differences were not statistically significant(P>0.05).The total satisfaction rate of the observation group was 90.54%(67/74),while the total satisfaction rate of the control group was 71.23%(52/73),the difference was statistically significant(χ2=8.846,P=0.012).The overall incidence of adverse reactions in the observation group was 4.05%(3/74),while in the control group it was 2.74%(2/73),the difference was not statistically significant(χ2=0.194,P=0.660).Conclusion Benzalkonium chloride combined with nystatin gargle can improve the nursing effect of chemotherapy related oral fungal infection,improve the quality of life and nursing satisfaction,and has high safety.
chemotherapy related oral fungal infectionsbenzalkonium chloridehematological tumorsrinse mouthquality of liferandomized controlled trial
万方数据
维普
