Analysis of Risk Factors of Syphilis Carriers Complicated With Neurosyphilis
Objective To explore the risk factors of neurosyphilis in syphilis carriers.Methods A total of 64 cases of syphilis carriers admitted in the People's Hospital of Yizheng from February 2021 to September 2023 were selected,among which 33 cases were complicated with neurosyphilis.Single-factor and multi-factor logistic regression analysis was conducted for the duration of positive rapid plasma reagin test(RPR)test,RPR titer,results of treponema pallidum particle agglutination assay(TPPA),albumin level in cerebrospinal fluid,human immunodeficiency virus(HIV),infection in cerebrospinal fluid,white blood cell count in cerebrospinal fluid,intracranial pressure,and whether formal syphilis treatment was accepted or not.Results RPR continued to be positive for more than one year,the titer of RPR was≥1:8,positive results of TPPA in cerebrospinal fluid and increased white blood cell count in cerebrospinal fluid were independent risk factors for syphilis carriers complicated with neurosyphilis(P<0.05),and receiving regular syphilis treatment was a protective factor to prevent syphilis carriers from complicated with neurosyphilis(P<0.05).Conclusion The probability of neurosyphilis is significantly increased in patients with syphilis RPR test lasting for more than one year and titer≥1:8,positive results of TPPA in cerebrospinal fluid and increased white blood cell count in cerebrospinal fluid,so these patients should receive regular treatment more actively.
万方数据
维普
