Effect of High Flux Hemodialysis on Treatment Effect and the Functional Status of Disease Treatment in Patients With Chronic Kidney Disease
Objective To explore the effect of high flux hemodialysis(HFH)on chronic kidney disease(CKD)patients and the influence of disease treatment functional status.Methods A total of 169 patients with CKD requiring hemodialysis from the Second Affiliated Hospital of Fujian Medical University from November 2020 to March 2023 were selected as the investigation objects,and were divided into control group(84 cases)and observation group(85 cases)by random number table method.The control group received routine hemodialysis treatment,while the observation group received HFH treatment.The differences in hemodialysis efficacy,disease treatment functional status,and sleep quality between the two groups of patients were compared.The efficacy of hemodialysis was evaluated by blood urea nitrogen(BUN),blood creatinine(Scr),serum homocysteine(Hcy),advanced glycation end products(AGEs)and so on.The functional assessment of chronic illness therapy-spiritual well-being(FACIT-Sp-12)and the Pittsburgh sleep quality index(PSQI)were used to evaluate the patients'disease treatment function status and sleep quality.Results After intervention,BUN and Scr levels in the observation group were(13.13±1.70)µg/L and(209.19±23.28)μmol/L,respectively,lower than(15.00±2.09)µg/L and(253.51±19.40)μmol/L in the control group,the differences were statistically significant(P<0.05).After intervention,the levels of Hcy and AGEs in the observation group were(21.78±3.19)µmol/L and(21.64±2.85)U/L,respectively,lower than(24.18±3.65)µmol/L and(24.20±3.41)U/L in the control group,the differences were statistically significant(P<0.05).After intervention,the FACIT-Sp-12 score of the observation group was(38.36±3.13)points,which was higher than that of the control group(34.64±3.29)points,and the difference was statistically significant(P<0.05).The PSQI score of the observation group was(11.24±2.12)points,lower than(12.28±2.09)points of the control group,and the difference was statistically significant(P<0.05).Conclusion HFH can improve the curative effect of patients with CKD,improve the functional state of patients with disease treatment,and improve the quality of sleep.
chronic kidney diseasehigh flux hemodialysisblood urea nitrogenquality of lifefunctional status of disease treatmentsleep quality
万方数据
维普
