Objective To explore the effect of esketamine used for sedation during cesarean section on newborns.Methods A total of 60 women who underwent elective lower uterine cesarean section in Affiliated Hospital of Shandong University of Traditional Chinese Medicine and Yantaishan Hospital,Yantai City from January 2022 to December 2023 were selected and randomly divided into esketamine group(group K,30 cases)and control group(group C,30 cases).After the subarachnoid anesthesia plane was fixed,the group K received intravenous injection of esketamine 0.2 mg/kg,and the group C received intravenous injection saline of equal volume.The traction discomfort and radial blood gas analysis were compared between the two groups.Blood was collected during fetal dissection,and blood gas analysis was performed on umbilical artery and umbilical vein.Results There were significant differences in HR and MAP between group K and group C at T2,T3,T4,T5 and T6(P<0.05).The time from the start of skin incision to fetal dissection in group K and group C was(10.10±1.37)min and(15.40±1.77)min(P<0.05).The incidence of traction discomfort in group C during pregnancy was higher than that in group K(P<0.05).The partial pressure of oxygen(PO2)in umbilical artery and umbilical vein in group K was higher than that in group C(P<0.05),and the blood lactic acid(Lac)was lower than that in group C(P<0.05).The oxygen saturation of hemoglobin(SO2)was higher than that of C group(P<0.05).No serious adverse reactions occurred in all pregnant women and newborns.Conclusion Esketamine can be safely used for sedation during cesarean section,and has no significant adverse effects on neonatal Apgar score and maternal and neonatal blood gas analysis.
关键词
艾司氯胺酮/镇静/产科/血气分析/不良反应/Ramsay镇静评分
Key words
esketamine/calm down/obstetrics/blood gas analysis/adverse reactions/Ramsay sedation scores
维普
万方数据