Observation of Repetitive Transcranial Magnetic Stimulation in the Treatment of Parkinson's Disease With Rapid Eye Movement Sleep Behavioral Disorders
Objective To explore the feasibility and safety of repeated repetitive transcranial magnetic stimulation in patients with Parkinson's disease with rapid eye movement sleep behavior disorder.Methods A retrospective analysis was conducted on the case data of Parkinson's disease patients with rapid eye movement sleep behavior disorder admitted to Fuzhou Second Hospital from March 2021 to March 2023.A total of 100 complete cases of Parkinson's disease patients with rapid eye movement sleep behavior disorder were reviewed and screened.According to the treatment plan,they were divided into two groups,with 50 cases in each group.The reference group received medication treatment,while the research group received repeated transcranial magnetic stimulation therapy on the basis of the reference group's treatment.The treatment effects between the two groups were compared.Results The total sleep time(TST),sleep efficiency(SE)and rapideyemovementsleep(REMS)of two groups of patients after treatment were higher than before,and the indicators of the study group after treatment[(360.45±25.68)min,(76.15±5.15)%,(12.85±4.32)min]were higher than those of the reference group[(317.85±23.12)min,(68.76±4.31)%,(8.05±1.65)min].However,sleeplatency(SL),arousalindex(AI)were lower than before treatment,and the indicators of the study group after treatment[(17.12±3.45)min,(24.05±2.48)time/h]were lower than those of the control group[(24.18±4.36)min,(35.36±3.12)time/h],with statistical significance(P<0.05).After treatment,the Epworth sleeping scale(ESS)scores of the two groups were lower than before treatment,and the post-treatment scores of the study group[(6.01±2.02)points]were lower than those of the reference group[(8.12±2.05)points],while the Montreal cognitive assess-ment scale(MoCA)score and PD sleep scale(PDSS)score were higher than before treatment,and the post-treatment scores of the study group[(25.38±2.76)points,(119.85±11.05)points]were significantly higher than those of the reference group[(22.38±2.13)points,(113.15±10.35)points],with statistical significance(P<0.05).The incidence of adverse reactions between two groups was not statistically significant(P>0.05).Conclusion The treatment of repetitive transcranial magnetic stimulation for Parkinson's disease patients with rapid eye movement sleep behavior disorder can obtain significant efficacy,which can effectively improve the patients'Sleep disorder,sleep quality and cognitive function,and will not increase the probability of adverse reactions in patients with high safety.
Parkinson's diseaserapid eye movement sleep behavior disorderrepetitive transcranial magnetic stimulationsleep qualitycognitive functionadverse reactions
万方数据
维普
