目的 分析慢性阻塞性肺疾病急性加重期(acute exacerbation phase of chronic obstructive pulmonary disease，AECOPD)炎症介质与肺功能的相关性。方法 选取 2021 年6 月—2023 年 6 月泰州市姜堰中医院收治的 110 例AECOPD患者为加重组，另外选取 71 例COPD患者作为稳定组，选取同期健康体检者 67 例作为对照组。观察 3 组患者一般资料、检测患者炎症介质、肺功能指标。分析不同肺功能分级患者炎症介质、肺功能指标水平，并分析炎症介质与肺功能的相关性。结果 与对照组相比，稳定组、加重组患者舒张压、收缩压、血肌酐、空腹血糖、白细胞(white blood cell，WBC)、降钙素原(procalcitonin，PCT)、超敏C反应蛋白(hypersensitive c reactive protein，hs-CRP)、白介素-6(interleukin-6，IL-6)、血清淀粉样蛋白A(serum amyloid A，SAA)表达水平逐渐升高，第 1 秒用力呼气容量/用力肺活量比值(forced expiratory volume in the first second/forced vital capacity，FEV1/FVC)、第 1 秒用力呼气容量(forced expiratory volume in the first second，FEV1)表达水平逐渐降低(P＜0。05)。与Ⅰ级相比，Ⅱ级、Ⅲ级患者PCT、hs-CRP、IL-6、SAA表达水平逐渐升高，FEV1/FVC、FEV1 水平逐渐降低(P＜0。05)。相关性分析显示，FEV1/FVC、FEV1水平与PCT、hs-CRP、IL-6、SAA呈负相关(P＜0。05)。多因素logistic回归分析显示，舒张压、收缩压、血肌酐、空腹血糖、WBC水平为AECOPD的主要危险因素(P＜0。05)。结论 AECOPD患者肺功能与炎症介质相关，检测患者炎症介质、肺功能状态，可用于患者病情的评估。
Correlation Between Inflammatory Mediators and Lung Function During the Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Objective To analyze the correlation between inflammatory mediators and lung function in acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods A total of 110 AECOPD patients admitted to Taizhou Jiangyan Hospital of Traditional Chinese Medicine from June 2021 to June 2023 were selected as the study subjects.In addition,71 COPD patients were selected as the stable group,and 67 healthy individuals who underwent physical examinations during the same period were selected as the control group.General information of patients in each group was observed,and inflammatory mediators and lung function indicators were detected.The levels of inflammatory mediators and lung function indicators in patients with different lung function grades,and analyze the correlation between inflammatory mediators and lung function were analyzed.Results Compared with the control group,patients in the stable and aggravated groups showed diastolic function Blood pressure,systolic blood pressure,blood creatinine,fasting blood glucose,white blood cell(WBC),procalcitonin(PCT),and hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),serum amyloid A(SAA).The expression level of SAA gradually increases,and the forced expiratory volume/forced lung in the first second force expiratory volume in the first second/force(FEV1/FVC),forced expiratory volume in the first second,the expression level of expiratory volume in the first second(FEV1)gradually decreased low(P<0.05).Compared with grade Ⅰ,the expression levels of PCT,hs-CRP,IL-6,and SAA in gradeⅡandⅢpatients gradually increased,and the levels of FEV1/FVC and FEV1 were also elevated gradually decrease(P<0.05).Correlation analysis showed that FEV1/FVC and FEV1 levels were negatively associated with PCT,hs-CRP,IL-6,and SAA(P<0.05).Multivariate logistic regression analysis showed that diastolic blood pressure,systolic blood pressure,blood creatinine,fasting blood glucose,and WBC levels were the main risk factors for AECOPD(P<0.05).Conclusion The lung function of AECOPD patients is related to inflammatory mediators,and the detection of inflammatory mediators and lung function status can be used to evaluate the patient's condition.
万方数据
维普
