Evaluation of the Therapeutic Effect of DEB-TACE for the Treatment of Hepatocellular Carcinoma in Child-Pugh Score 8
Objective To analyze and study the therapeutic effect of DEB-TACE on hepatocellular carcinoma with a Child Pugh score 8 in liver function.Methods From November 2021 to November 2022,a total of 20 cases of liver cancer with Child-Pugh grade B score 8 were continuously enrolled in Anqing Municipal Hospital,and all of them received DEB-TACE treatment.The changes of liver function and adverse reactions before and after treatment were analyzed.Results All 20 cases in this group were treated with CalliSpheres drug-loaded microspheres,and the process was smooth.One month after surgery,2 cases had disease progression(PD),11 cases partial response(PR),2 cases complete response(CR),and 5 cases stable disease(SD),and the objective response rate(ORR)was 65.0%(13/20).7 cases received target immune system therapy.The levels of aspartate transaminase(AST),total bilirubin,and alanine transaminase(ALT)all increased one week after surgery,and the differences were statistically significant.Comparison of changes in albumin levels,there was no statistically significant difference(P>0.05).Compared with preoperative treatment,after one month of surgical treatment,the patient's liver function basically returned to normal levels,and the difference was not statistically significant(P>0.05).The patient had only mild adverse reactions,such as pain,fever,nausea,vomiting,etc.Conclusion The short-term efficacy of DEB-TACE in the treatment of hepatocellular carcinoma with liver function Child-Pugh score of 8 is accurate and safe.
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