Correlation Study Between EGFR Gene Mutation and CT Imaging Features of Non-Small Cell Lung Cancer
Objective To analyze the correlation between CT imaging features of non-small cell lung cancer and gene mutations of the epidermal growth factor receptor(EGFR).Methods Clinical data of 256 patients with non-small cell lung cancer diagnosed in Baotou Cancer Hospital from January 2020 to December 2023 were retrospectively analyzed.EGFR mutation gene detection was performed in all patients.96 patients with effective EGFR mutation were taken as positive group,and 160 patients with no effective EGFR mutation were taken as negative group.The results of chest CT scan were analyzed,the relevant CT imaging data were collected,and the correlation between CT imaging features of non-small cell lung cancer and EGFR was analyzed by logistic regression.Results The proportion of patients with burr,lobed shape,clear edge,semi-solid lesion density,airway bronchial sign,pleural depression sign,cancerous lymphangitis,lung metastasis and uneven enhancement in positive group was higher than that in negative group,the difference was statistically significant(P<0.05).There was no significant difference in the proportion of lesion necrosis,calcification,cavity,halo sign,vacuole sign,pleural effusion,lymph node metastasis,pleural metastasis and distant metastasis between 2 groups(P>0.05).Logistic regression analysis showed that lobulation,spiculation,semi-solid density and heterogeneous enhancement were the influential factors of EGFR gene mutation in non-small-cell lung carcinoma patients(P<0.05).Conclusion Non-small cell lung carcinoma imaging features are closely associated with EGFR mutant genes,and the presence of non-small cell lung carcinoma EGFR mutant genes can be predicted by lobulation,burr,ground-glass opacity,and heterogeneous enhancement.
万方数据
维普
