首页|65例胃早癌脉管侵犯的相关因素分析

65例胃早癌脉管侵犯的相关因素分析

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目的 探讨胃早癌脉管侵犯的相关因素。方法 回顾性分析江苏省扬州市江都人民医院 2018 年 1 月—2023 年 6 月收治的 65 例胃早癌内镜黏膜下剥离术(endoscopic submucosal dissection,ESD)患者资料。根据术后病理结果将患者分为脉管侵犯组与非侵犯组,分别为 31 例和 34 例。分析各组病例的临床特征、胃镜表现及病理特点,通过logistic回归分析探讨胃癌发生脉管浸润的独立危险因素。结果 病灶>2 cm(OR= 4。959,95%CI 1。490~16。500)、合并溃疡(OR= 3。667,95%CI 1。429~21。950)、Kit-67 指数>30%(OR= 9。601,95%CI 2。530~36。373)、病理分化差(OR= 6。440,95%CI 1。822~22。760)及浸润深度T1b(tumour infiltration depth 1b,T1b)(OR= 6。301,95%CI 1。913~20。802)对胃早癌脉管侵犯有影响(P<0。05)。Kit-67 指数>30%是脉管转移独立高危因素(P<0。05)。结论 脉管侵犯与多种因素有关,Kit-67 指数对评估是否合并脉管侵犯有重要临床意义。
Analysis of Related Factors of Vascular Invasion in 65 Cases of Early Gastric Cancer
Objective To explore the factors related to vascular invasion in early gastric cancer.Methods This article reviewed the data of 65 patients with endoscopic submucosal dissection(ESD)in Jiangdu People's Hospital of Yangzhou,Jiangsu Province from January 2018 to June 2023.According to the postoperative pathological results,the patients were divided into vascular invasion group and non-invasion group,31 cases and 34 cases respectively.The clinical features,gastroscopy and pathological features of each group were analyzed,and the independent risk factors for vascular infiltration of gastric cancer were investigated by logistic regression analysis.Results Lesion>2 cm(OR=4.959,95%CI 1.490 to 16.500),ulcer(OR=3.667,95%CI 1.429 to 21.950),Kit-67 index>30%(OR=9.601,95%CI 2.530 to 36.373),poor pathological differentiation(OR=6.440,95%CI 1.822 to 22.760)and tumour infiltration depth 1b(T1b)(OR=6.301,95%CI 1.913 to 20.802)had influence on vascular invasion of early gastric cancer(P<0.05).Kit-67 index>30%was an independent high-risk factor for vascular metastasis(P<0.05).Conclusion Vascular invasion is associated with multiple factors,and the Kit-67 index has important clinical significance in evaluating whether there is concurrent vascular invasion.

early stomach cancerESDsze of the lesioncomplicated with ulcerKit-67 indexpoor pathological differentiationtumour infiltration depth

刘克伟、鲍丽静、蒋丰娟、林加湘、张鹏飞、孙乐

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江苏省扬州市江都人民医院消化内科,江苏扬州 225002

江苏省扬州市江都人民医院肿瘤内科,江苏扬州 225002

胃早癌 ESD 病灶大小 合并溃疡 Kit-67 病理分化差 浸润深度

2024

中国卫生标准管理
《中国卫生标准管理》杂志社

中国卫生标准管理

影响因子:1.374
ISSN:1674-9316
年,卷(期):2024.15(8)
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