Objective To analyze the relationship between p53 gene mutation and clinicopathological features in breast cancer tissues with low expression of human epidermal growth factor receptor 2(HER2).Methods A total of 112 patients with breast cancer with low HER2 expression admitted to the Third Hospital of Xiamen from August 2018 to August 2023 were selected as the study objects.All patients underwent surgical resection of cancer tissues and retained breast cancer tissues in the Third Hospital of Xiamen.Polymerase chain reaction single strand conformation polymorphism(PCR-SSCP)was used to detect p53 gene mutation in breast cancer tissues with low HER2 expression,and the correlation between p53 gene mutation and clinicopathological characteristics of breast cancer with low HER2 expression was analyzed.Results In breast cancer tissues with low expression of HER2,82 cases(73.21%)had no mutation of p53 gene,and 30 cases(26.79%)had mutation of p53 gene.p53 gene mutation was positively correlated with tumor diameter,lymph node metastasis,vascular invasion and clinical stage(P<0.05).Age,body mass index(BMI),cell proliferation-associated antigens(Ki-67)index,estrogen receptor(ER)were evaluated p53 gene mutation was associated with tumor diameter,lymph node metastasis,vascular invasion and clinical stage after receptor,ER index and other factors were controlled(P<0.05).Conclusion The p53 gene mutation rate in breast cancer tissues with low HER2 expression is low,and p53 gene mutation is correlated with tumor diameter,lymph node metastasis,vascular invasion,and clinical stage of breast cancer,which provides references for the formulation of breast cancer diagnosis and treatment guidelines and later standards for the Chinese Anti-Cancer Association.
关键词
乳腺癌/p53基因/人类表皮生长因子受体/临床病理特征/相关性/淋巴结转移
Key words
breast cancer/p53 gene/human epidermal growth factor receptor/clinicopathological features/correlation/lymph node metastasis
维普
万方数据