Effect of Hemoperfusion Combined With High-Throughput Hemodialysis on Myocardial Protection in Acute Organophosphate Poisoning Patients
Objective To investigate the effect of blood perfusion combined with high-throughput hemodialysis in patients with acute organophosphorus poisoning.Methods A total of 60 patients with acute organophosphorus poisoning admitted to Putian 95 Hospital from September 2019 to September 2021 were selected.They were randomly divided into control group(30 cases)and observation group(30 cases).Both groups were given routine treatment after admission.Patients in the control group were treated with hemoperfusion,and patients in the observation group received hemoperfusion combined with high-throughput hemodialysis treatment.The total effective rate,myocardial injury markers,nerve tissue markers,treatment success rate and treatment satisfaction were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05).There was no significant difference in cardiac troponin(cTnI),creatine kinase(CK),lactate dehydrogenase(LDH)and creatine kinase isoenzyme(CK-MB)between 2 groups before treatment(P>0.05).After treatment,cTnI,CK,LDH and CK-MB in 2 groups were lower than before treatment,and observation group was lower than control group(P<0.05).After treatment,cholinesterase(CHE)and neuron-specificenolase(NSE)in 2 groups were higher than before treatment,and CHE in observation group was higher than control group,NSE was lower than control group(P<0.05).The success rate of treatment and total satisfaction in the observation group were 100%and 96.67%,which were higher than 86.67%and 76.92%in the control group(P<0.05).Conclusion Hemfusion and high-throughput hemodialysis in acute organophosphorus poisoning have good effect on myocardial function,effectively improve the myocardial injury of patients,and improve the efficiency and satisfaction of treatment.
万方数据
维普
