Assessment Value of Keratin 19,C-Reactive Protein and Albumin Indexes on Postoperative Efficacy and Prognosis of Colorectal Cancer
Objective To analyze the clinical efficacy and predictive value of detecting keratin 19,C-reactive protein and albumin in postoperative colorectal cancer patients.Methods A total of 98 patients admitted to Xinjiang Uygur Municipal People's Hospital from January 2021 to January 2022 were selected as the study subjects.The clinical efficacy and prognosis of keratin 19,C-reactive protein,and albumin levels were compared before and after clinical treatment.The estimated clinical value was evaluated using receiver operating characteristic(ROC)curves.Results After treatment,the levels of keratin 19,C-reactive protein,and albumin in the patients decreased compared to before treatment,the differences were statistically significant(P<0.05).The levels of keratin 19 and C-reactive protein in the group with good curative effect were lower than those in the group with poor curative effect,and albumin was higher than those in the group with poor curative effect,the difference was statistically significant(P<0.05).The levels of keratin 19 and C-reactive protein in survival group were lower than those in death group,and albumin was higher than those in death group,the difference was statistically significant(P<0.05).Based on the ROC curve,the area under the curve(AUC)values of keratin 19,C-reactive protein,and albumin were 0.822,0.921 and 0.899,all exceeding 0.7,which has predictive value for poor prognosis of rectal cancer.The sensitivity,specificity,AUC value,and Yoden index of the combined detection of the three indicators were higher than those of the single detection of the three indicators,and the difference was statistically significant(P<0.05).Conclusion The detection of keratin 19,C-reactive protein,and albumin can effectively predict the changes in therapeutic efficacy and prognosis of colorectal cancer patients.
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