Application Effect of Dagliazine in Patients With Heart Failure With Preserved Ejection Fraction and Type 2 Diabetes Mellitus
Objective To observe the clinical efficacy of daglizin in patients with heart failure with preserved ejection fraction(HFpEF)combined with type 2 diabetes mellitus(T2DM).Methods A total of 80 HFpEF patients with T2DM in the department of cardiology,Suqian TCM Hospital from August 2021 to July 2023 were selected and randomly divided into control group(40 cases)and observation group(40 cases).Patients in 2 groups were given anti-heart failure drug treatment according to the guidelines,control group was given metformin,observation group was given metformin combined with daglizin.Fasting blood glucose(FBG),postprandial 2 h blood glucose(2 hPG),glycohemoglobin(HbA1c),N terminal pro B type natriuretic peptide(NT-ProBNP),left ventricular ejection fraction(LVEF),left ventricular end-systolic diameter(LVEDs),left ventricular end-diastolic diameter(LVEDd)and New York Heart Association(NYHA)were recorded and followed up before treatment,1 month and 3 months after treatment in 2 groups to evaluate clinical efficacy and record adverse drug reactions.Results The total effective rate of the observation group was 87.50%,higher than that of the control group(67.50%),and the difference was statistically significant(P<0.05).At 1 month and 3 months after treatment,FBG,2 hPG and HbA1c in observation group were lower than those in control group(P<0.05).At 1 month and 3 months after treatment,NT-ProBNP and LVEF between the 2 groups were compared,and the difference was statistically significant(P<0.05).NYHA cardiac function grade in observation group was significantly improved compared with control group after treatment(P<0.05).No adverse drug reactions such as hypotension,hypoglycemia,genital fungal infection,nasopharyngitis and urinary tract infection occurred in the two groups during hospitalization and follow-up.Conclusion Dagliazine can significantly reduce blood glucose level and improve cardiac function in HFpEF patients with T2DM,with good safety.
万方数据
维普
