Application of CT Perfusion Imaging in Identification and Diagnosis of Benign and Malignant Solitary Pulmonary Nodules
Objective To explore the application value of CT perfusion imaging in the identification and diagnosis of benign and malignant solitary pulmonary nodules.Methods The clinical data of 68 patients with solitary pulmonary nodules treated in Nan'an Hospital from January 2022 to March 2023 were retrospectively analyzed.The patients were divided into benign nodule group(n=43)and malignant nodule group(n=25)according to the results of percutaneous pulmonary puncture pathological biopsy,fiberoptic biopsy and surgical pathology.CT perfusion imaging was performed before pathological biopsy.The relevant parameters of CT perfusion imaging were compared between the two groups.Results There were no significant difference in mean transit time(MTT)values between the two groups(P＞0.05).The blood flow(BF),blood volume(BV),capillary permeability surface area product(PS)values in the malignant nodule group were significantly higher than those in the benign nodule group(P＜0.05).According to receiver operating characteristic(ROC)curve analysis,when the BF threshold was 72.175 mL/(100 g·min),BV threshold was 4.815 mL/100 g,and PS threshold was 8.190 mL/(100 g·min),the area under the curve for identifying benign and malignant nodules were 0.910,0.935,0.956,and the sensitivity were 84.00%,96.00%,and 92.00%,respectively.Conclusion CT perfusion imaging can visually display the full view of solitary pulmonary nodules,and the parameters BV,BF and PS values of CT perfusion imaging have high clinical value in distinguishing between benign and malignant nodules.
solitary pulmonary nodulesCT perfusiondifferential diagnosisbenign or malignantblood volumepermeability surface
万方数据
维普
