Study on the Efficacy of Flurbiprofen Axetil Combined With Dezocine in Elderly Patients Undergoing Total Hip Arthroplasty
Objective To investigate the effects of flurbiprofen axidate combined with dezocine on stress response and inflammatory factors in elderly patients undergoing total hip arthroplasty.Methods A total of 130 elderly patients with total hip arthroplasty admitted to Wuyishan City Hospital from March 2021 to March 2023 were randomly divided into the observation group(n=65)and the control group(n=65).Both groups were given intravenous general anesthesia.The control group was given dezocine preemptive analgesia,and the observation group was given flurbiprofen axetil combined with dezocine preemptive analgesia.The postoperative recovery quality,postoperative pain degree,postoperative stress response index level,inflammatory response index and adverse reactions were compared between the two groups.Results The visual analogue scale(VAS)scores of the observation group at 2,6,12 and 24 h after surgery were(6.09±0.98)points,(4.12±0.80)points,(2.29±0.57)points and(1.26±0.33)points,respectively.It was lower than that of control group(6.85±1.03)points,(4.79±0.85)points,(2.80±0.62)points,(1.71±0.42)points(P<0.05).The postoperative recovery quality indicators of the observation group were better than those of the control group(P<0.05).At 24 h after operation,the levels of adrenaline(AD),norepinephrine(NE)and cortisol(Cor)in the observation group were lower than those in the control group(P<0.05).At 24 h after operation,the levels of inflammatory factors interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)and hypersensitive C-reactive protein(hs-CRP)in the observation group were lower than control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Flurbiprofen axetil injection combined with dezocine preemptive analgesia has a good analgesic effect on elderly patients undergoing total hip arthroplasty.It can improve the quality of recovery,inhibit the level of stress response,improve the inflammatory response,and has good safety.
total hip arthroplastyflurbiprofen axetildezocinepreemptive analgesiaquality of awakeningstress reactioninflammatory factors
万方数据
维普
