Effect of Low Molecular Weight Heparin in the Treatment of Recurrent Miscarriage After Pregnancy in Human Assisted Reproductive Technology
Objective To investigate the effect of low molecular weight heparin in the treatment of recurrent miscarriage after pregnancy in human assisted reproductive technology.Methods A total of 68 patients with recurrent abortion treated with fetal preservation after successful pregnancy using human assisted reproductive technology in Putian 95 Hospital from June 2020 to June 2022 were selected as the study objects,and randomly divided into 2 groups,with 34 patients in each group.The control group received conventional treatment,and the study group received conventional treatment+low molecular weight heparin treatment.Coagulation function indexes,hormone levels,pregnancy outcomes and adverse reactions were compared between the two groups before and after treatment.Results After treatment,D-dimer(D-D)and fibrin water in 2 groups were lower than before treatment,and the study group was lower than the control group(P<0.05).After treatment,progesterone(P),human chorionic gonadotropin(HCG),estradiol(E2)levels in 2 groups were higher than before treatment,and the study group was higher than the control group(P<0.05).The full-term productivity of the study group was 70.59%,higher than that of the control group(41.18%).The abortion rate in the study group was 17.65%,which was lower than 44.12%in the control group(P<0.05).There was no significant difference in the preterm birth rate between the study group and the control group(P>0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Treatment with low molecular weight heparin in patients with recurrent miscarriage after successful pregnancy through human assisted reproductive technology can improve the hormone levels and coagulation function indicators of patients,improve term productivity,and do not increase adverse reactions.
low molecular weight heparinrecurrent miscarriagehuman assisted reproductive technologypregnancyhormonescoagulation function
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维普
