摘要
目的 回顾性分析无锡地区 2021 年 1 月—2023 年 11 月成人感染肺炎支原体对抗菌药物的敏感性,为临床用药提供参考依据.方法 回顾性分析 2021 年 1 月—2023 年 11 月来上海交通大学医学院附属瑞金医院无锡分院就诊患者呼吸道感染的 104 株肺炎支原体,对 14 种常见抗菌药物的耐药性.结果 104 株肺炎支原体中,耐乙酰螺旋霉素 57 株(54.8%),耐莫西沙星 45 株(43.3%),耐强力霉素 34 株(32.7%),耐美满霉素 26 株(25.0%),耐环丙沙星 16 株(15.4%),耐克林霉素 14 株(13.5%);耐依托红霉素、加替沙星、交沙霉素、左氧氟沙星、阿奇霉素、克拉霉素、红霉素及罗红霉素均在9 株以下.结论 对成人呼吸道感染的肺炎支原体,临床应以大环内酯类和喹诺酮类抗菌药物进行治疗,但应避免使用大环内酯类中的乙酰螺旋霉素和喹诺酮类中的莫西沙星和环丙沙星.
Abstract
Objective To retrospectively analyze drug resistance of Mycoplasma pneumonia in adults with respiratory tract infections in Wuxi region from January 2021 to November 2023,and provide information for infection therapy.Methods Drug resistance of 104 strains of mycoplasma pneumonia from the respiratory tract of adult patients to 14 antimicrobial drugs used for treatment was retrospectively analyzed from January 2021 to November 2023 in Wuxi Branch,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine.Results Mycoplasma pneumonia showed a high rate of resistance to some of the commonly prescribed antimicrobial drugs:acetylspiramycin(54.8%,57 strains),moxifloxacin(43.3%,45 strains),doxycycline(32.7%,34 strains),minocycline(25.0%,26 strains),ciprofloxacin(15.4%,16 strains),clindamycin l(13.5%,14 strains),a low rate of resistance to other commonly prescribed antimicrobial drugs such as erythromycin,gatifloxacin,josamycin,levofloxacin,azithromycin,clarithromycin,erythromycin,and roxithromycin(less than 9 strains).Conclusion Respiratory tract infections with Mycoplasma pneumoniae in adult should be treated with macrolides and quinolones,but but acetylspiramycin(a macrolide)and moxifloxacin and ciprofloxacin(quinolones)should be avoided.
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