A Meta-Analysis of the Efficacy of Bevacizumab in Combination With Chemoradiotherapy in Cervical Cancer
Objective To evaluate the efficacy and safety of bevacizumab combined with chemoradiotherapy in the treatment of cervical cancer.Methods The studies on the treatment of cervical cancer in the Chinese database PubMed et al.were searched,and the randomized controlled trials from 2010 to 2023 were collected.Review Manager 4.2 was used to analyze the incidence of complete response,partial response,stable disease,and adverse reactions in patients.Funnels were plotted to assess publication bias.Results Nine articles in the literature with a total of 654 patients(327 in the experimental group and 327 in the control group)were included.Bevacizumab combined with chemoradiotherapy increased the incidence of complete remission,partial remission,and disease stabilization in patients with cervical cancer,and there was no difference in the incidence of adverse reactions compared with chemoradiotherapy alone(P>0.05).Funnel plots show that the included studies were not considered to be at publication bias.Conclusion The efficacy of bevacizumab combined with chemoradiotherapy in the treatment of cervical cancer was better than that of chemoradiotherapy alone,and the incidence of adverse reactions was similar to that of chemoradiotherapy alone.
cervical cancerbevacizumabconcurrent chemoradiotherapyrandom control dataMeta analysiscurative effect
NETL
NSTL
万方数据
