贝伐珠单抗联合放化疗对宫颈癌疗效的Meta分析
A Meta-Analysis of the Efficacy of Bevacizumab in Combination With Chemoradiotherapy in Cervical Cancer
毛先华 1曾彩虹 2孙移娇 1王志文 1任森 3霍伦3
作者信息
- 1. 岳阳职业技术学院慢性病重点实验室,湖南岳阳 414006
- 2. 湖南师范大学附属岳阳医院/岳阳市人民医院妇科,湖南 岳阳 414000
- 3. 长沙卫生职业学院临床学院,湖南长沙 410100
- 折叠
摘要
目的 评价贝伐珠单抗联合放化疗治疗宫颈癌的疗效及治疗过程中的安全性.方法 对中文数据库维普及英文数据库PubMed等中关于贝伐珠单抗联合放化疗治疗宫颈癌的研究进行检索,收集 2010-2023 年相关的随机对照试验.采用Review Manager 4.2 软件分析患者的完全缓解、部分缓解、疾病稳定及不良反应的发生率,绘制漏斗图评价发表偏倚情况.结果 纳入符合本研究的文献 9 篇,共 654 例患者(试验组 327例,对照组 327 例).贝伐珠单抗联合放化疗可提高宫颈癌患者完全缓解、部分缓解和疾病稳定的发生率,不良反应的发生率与单纯放化疗相比,差异无统计学意义(P＞0.05).漏斗图显示纳入的研究尚不认为存在发表偏倚.结论 贝伐珠单抗联合放化疗治疗宫颈癌的疗效优于单纯放化疗,与单纯放化疗不良反应的发生率相近.
Abstract
Objective To evaluate the efficacy and safety of bevacizumab combined with chemoradiotherapy in the treatment of cervical cancer.Methods The studies on the treatment of cervical cancer in the Chinese database PubMed et al.were searched,and the randomized controlled trials from 2010 to 2023 were collected.Review Manager 4.2 was used to analyze the incidence of complete response,partial response,stable disease,and adverse reactions in patients.Funnels were plotted to assess publication bias.Results Nine articles in the literature with a total of 654 patients(327 in the experimental group and 327 in the control group)were included.Bevacizumab combined with chemoradiotherapy increased the incidence of complete remission,partial remission,and disease stabilization in patients with cervical cancer,and there was no difference in the incidence of adverse reactions compared with chemoradiotherapy alone(P>0.05).Funnel plots show that the included studies were not considered to be at publication bias.Conclusion The efficacy of bevacizumab combined with chemoradiotherapy in the treatment of cervical cancer was better than that of chemoradiotherapy alone,and the incidence of adverse reactions was similar to that of chemoradiotherapy alone.
关键词
宫颈癌/贝伐珠单抗/同步放化疗/随机对照资料/Meta分析/疗效Key words
cervical cancer/bevacizumab/concurrent chemoradiotherapy/random control data/Meta analysis/curative effect引用本文复制引用
基金项目
湖南省职业院校教育教学改革研究项目(2021)(ZJBZ2021140)
出版年
2024
NETL
NSTL
万方数据