Effect of Low Molecular Weight Heparin Sodium on Acute Moderate-risk Pulmonary Embolism
Objective To analyze the clinical effect of low molecular weight heparin sodium in the treatment of acute moderate-risk pulmonary embolism.Methods A total of 80 patients with acute moderate-risk pulmonary embolism who underwent surgical treatment in Sanming First Hospital Affiliated to Fujian Medical University from January 2020 to December 2022 were selected as the study objects,and were divided into experimental group(40 cases)and control group(40 cases)by digital randomization method.Both groups received conventional basic treatment,while the control group was treated with warfarin and alteplase,and the experimental group was treated with low molecular weight heparin sodium on the basis of the control group.The therapeutic effect,occurrence of adverse reactions,laboratory indexes(serum brain natriuretic peptide,troponin,pulmonary artery systolic pressure),coagulation function(prothrombin time,fibrinogen,activated partial thromboplastin time)and inflammatory factors(interleukin-6,C-reactive protein)were compared between the two groups.Results The total effective rate of experimental group(97.50%)was higher than that of control group(82.50%),and the difference was statistically significant(P=0.025).There was no significant difference in the incidence of adverse reactions between experimental group and control group(10.00%and 7.50%)(P=0.692).After treatment,the levels of brain natriuretic peptide,troponin and pulmonary artery systolic pressure in experimental groups were lower than those in control group,and the differences were statistically significant(P<0.001).After treatment,the prothrombin time and activated partial thromboplastin time of experimental group were longer than those of control group,and the fibrinogen level of experimental group was lower than that of control group,with statistical significances(P<0.001).After treatment,the prothrombin time and activated partial thromboplastin time of experimental group were longer than those of control group,and the fibrinogen level of experimental group was lower than that of control group,with statistical significances(P<0.001).After treatment,the levels of interleukin-6 and C-reactive protein in experimental group[(1.02±0.19)pg/mL,(3.19±0.62)mg/L]were lower than those in control group[(1.28±0.22)pg/mL,(4.25±0.72)mg/L],the differences were statistically significant(P<0.001).Conclusion Low molecular weight heparin sodium in the treatment of acute moderate-risk pulmonary embolism has good clinical effect,can effectively improve blood viscosity and inflammatory response,reduce pulmonary artery pressure,increase cardiac output,and good safety.
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