On the urgent calling for clinical orientation,laboratory medicine should more focus on collaboration with clinical practice to improve treatment performance.As a response,this article embodies the ISO15189 in line with the international standard"Accreditation Standards for the Quality and Competence of Medical Laboratories"CNAS-AL09:2020"Accreditation Criteria for Quality and Competence of Medical Laboratories".This paper puts forward the perspective of total quality management in the cooperation between laboratory medicine and clinical practice:in pre-analysis stage,improve information checking and operation training for higher specimen validity;for communication with clinical departments in analysis stage,adopt efficient data information management approaches in abnormal result interpretation;and pay more attention to the extension of laboratory work in post-analysis stage.