抗生素降阶梯方案对48例重症肺炎患者的疗效分析
Analysis of the Therapeutic Effect of Antibiotic Downgrading Regimen on 48 Patients With Severe Pneumonia
韩亮 1张婷婷2
作者信息
- 1. 兖矿新里程总医院重症医学科,山东 邹城 273500
- 2. 兖矿新里程总医院血液内科,山东 邹城 273500
- 折叠
摘要
目的 探讨重症肺炎患者接受抗生素降阶梯方案治疗的效果.方法 选择 2020 年 1 月—2022 年 12 月兖矿新里程总医院收治的重症肺炎患者 96 例,根据随机盲选的方式将其分为对照组与试验组,各 48 例.所有患者在入院后均接受常规基础治疗,对照组在治疗期间给予传统抗生素治疗,试验组则给予抗生素阶梯方案治疗.对比 2 组的治疗效果、抗生素使用时间、肺啰音消失时间、感染控制时间、住院时间及 2 组治疗前后的炎症因子水平.结果 对照组的总有效率为 72.92%,试验组的总有效率为 91.67%,差异有统计学意义(P＜0.05).观察组的抗生素使用时间为(10.13±3.22)d,肺啰音消失时间为(12.31±1.89)d,感染控制时间为(11.16±2.08)d,住院时间为(14.32±2.73)d,明显低于对照组的(17.05±4.36)d、(15.70±2.65)d、(19.33±1.39)d、(19.91±3.38)d,差异有统计学意义(P＜0.05).治疗前,2组的降钙素原(procalcitonin,PCT)、D-二聚体(D-Dimer,D-D)、C反应蛋白(C-reactive protein,CRP)等水平相比,差异无统计学意义(P＞0.05);治疗后,试验组的PCT为(2.09±0.43)ng/L、D-D为(0.65±0.17)μg/L、CRP 为(5.61±1.06)mg/L,明显低于对照组的(3.12±0.76)ng/L、(1.41±0.29)μg/L、(8.57±1.43)mg/L,差异有统计学意义(P＜0.05).结论 在重症肺炎的治疗中,采用抗生素降阶梯方案治疗效果确切,能快速改善其症状,促进其病情康复,还能降低炎症因子水平.
Abstract
Objective To explore the effectiveness of antibiotic therapy in patients with severe pneumonia.Methods A total of 96 patients with severe pneumonia admitted to Yankuang New Journey General Hospital were selected for the study from January 2020 to December 2022.According to random blind selection,patients were divided into a control group and an experimental group,with 48 cases in each group.All patients received routine basic treatment after admission,while the control group received traditional antibiotic treatment during the treatment period,and the experimental group received antibiotic ladder therapy.The treatment effect,the antibiotic use time,lung rale disappearance time,infection control time,hospital stay,and other indicators and compare the levels of inflammatory factors before and after treatment between the two groups were compared.Results The total effective rate of the control group was 72.92%,while the total effective rate of the experimental group was 91.67%,the differences were statistically significant(P<0.05).The duration of antibiotic use in the observation group was(10.13±3.22)days,the disappearance time of lung rales was(12.31±1.89)days,the infection control time was(11.16±2.08)days,and the hospital stay was(14.32±2.73)days,which was significantly lower than the control group's(17.05±4.36)days,(15.70±2.65)days,(19.33±1.39)days and(19.91±3.38)days,with statistical significance(P<0.05).Before treatment,there was no significant difference in levels of procalcitonin(PCT),D-dimer(D-D)and C-reactive protein(CRP)between the control group and the experimental group(P>0.05).After treatment,the PCT of the experimental group was(2.09±0.43)ng/L,and the D-D was(0.65±0.17)μg/L,the levels of CRP(5.61±1.06)mg/L were significantly lower than those of the control group(3.12±0.76)ng/L and(1.41±0.29)μg/L,(8.57±1.43)mg/L,the differences were statistically significant(P<0.05).Conclusion In the treatment of severe pneumonia,the use of antibiotic and antibiotic downgrading regimen has a definite effect,can quickly improve its symptoms,promote its recovery,and also reduce the level of inflammatory factors.
关键词
重症肺炎/抗生素降阶梯方案/治疗效果/症状改善时间/住院时间/炎症因子Key words
severe pneumonia/antibiotic downgrading plan/therapeutic effect/symptom improvement time/hospitalization time/inflammatory factors引用本文复制引用
出版年
2024
NETL
NSTL
万方数据