Analysis of the Therapeutic Effect of Antibiotic Downgrading Regimen on 48 Patients With Severe Pneumonia
Objective To explore the effectiveness of antibiotic therapy in patients with severe pneumonia.Methods A total of 96 patients with severe pneumonia admitted to Yankuang New Journey General Hospital were selected for the study from January 2020 to December 2022.According to random blind selection,patients were divided into a control group and an experimental group,with 48 cases in each group.All patients received routine basic treatment after admission,while the control group received traditional antibiotic treatment during the treatment period,and the experimental group received antibiotic ladder therapy.The treatment effect,the antibiotic use time,lung rale disappearance time,infection control time,hospital stay,and other indicators and compare the levels of inflammatory factors before and after treatment between the two groups were compared.Results The total effective rate of the control group was 72.92%,while the total effective rate of the experimental group was 91.67%,the differences were statistically significant(P<0.05).The duration of antibiotic use in the observation group was(10.13±3.22)days,the disappearance time of lung rales was(12.31±1.89)days,the infection control time was(11.16±2.08)days,and the hospital stay was(14.32±2.73)days,which was significantly lower than the control group's(17.05±4.36)days,(15.70±2.65)days,(19.33±1.39)days and(19.91±3.38)days,with statistical significance(P<0.05).Before treatment,there was no significant difference in levels of procalcitonin(PCT),D-dimer(D-D)and C-reactive protein(CRP)between the control group and the experimental group(P>0.05).After treatment,the PCT of the experimental group was(2.09±0.43)ng/L,and the D-D was(0.65±0.17)μg/L,the levels of CRP(5.61±1.06)mg/L were significantly lower than those of the control group(3.12±0.76)ng/L and(1.41±0.29)μg/L,(8.57±1.43)mg/L,the differences were statistically significant(P<0.05).Conclusion In the treatment of severe pneumonia,the use of antibiotic and antibiotic downgrading regimen has a definite effect,can quickly improve its symptoms,promote its recovery,and also reduce the level of inflammatory factors.
severe pneumoniaantibiotic downgrading plantherapeutic effectsymptom improvement timehospitalization timeinflammatory factors
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