Objective To investigate the effects of ticagrelor on left ventricular remodeling and cardiac function after acute myocardial infarction(AMI)in mice.Methods Eight-week-old male C57BL/6 mice were randomly divided into five groups:Sham group,AMI group,ticagrelor treatment group,ticagrelor pretreatment group,and ticagrelor pretreatment+treatment group.All groups,except for the Sham group,underwent left anterior descending coronary artery ligation to establish an AMI model.The ticagrelor treatment group received medication post-modeling,the pretreatment group pre-modeling,and the pretreatment+treatment group both pre-and post-modeling.Groups were compared for left ventricular function[left ventricular fractional shortening(LVFS),left ventricular end-diastolic diameter(LVEDD),and left ventricular end-systolic diameter(LVESD)],inflammatory markers[IL-6 and TNF-α],cardiac index,and mRNA expression levels of serum atrial natriuretic peptide(ANP)and brain natriuretic peptide(BNP).Results The left ventricular fractional shortening(LVFS)of the Sham group,the Ticagrelor treatment group,and the Ticagrelor pretreatment+treatment group[(42.12±5.20)%,(39.63±5.75)%,and(41.72±6.31)%]was higher than that of the AMI group[(33.98±5.21)%],with a statistically significant difference(P<0.05).In contrast,the left ventricular end-diastolic diameter(LVEDD)and left ventricular end-systolic diameter(LVESD)were lower in the Sham group,the Ticagrelor treatment group,and the Ticagrelor pretreatment+treatment group[(3.59±0.61)mm,(4.03±0.65)mm,and(3.96±0.73)mm compared to(4.79±0.74)mm;(2.13±0.40)mm,(2.39±0.56)mm,and(2.29±0.48)mm compared to(2.93±0.54)mm],with statistically significant differences(P<0.05).The levels of inflammatory factors IL-6 and TNF-α in the Sham group,the Ticagrelor treatment group,and the Ticagrelor pretreatment+treatment group were lower than those in the AMI group[(110.50±25.34)pg/mL,(202.28±55.24)pg/mL,and(189.49±43.31)pg/m L vs.(359.48±80.10)pg/mL;(24.59±6.95)pg/mL,(51.28±14.03)pg/mL,and(47.49±11.16)pg/mL vs.(81.92±15.55)pg/mL],with statistically significant differences(P<0.001).The cardiac index of the Sham group,the Ticagrelor treatment group,and the Ticagrelor pretreatment+treatment group were(4.90±0.84),(5.44±0.90),and(5.31±0.84),respectively,which were lower than that of the AMI group(6.39±1.29),with a statistically significant difference(P<0.05).The cardiac index of the Ticagrelor pretreatment group was(6.21±1.04)points,with no statistically significant difference compared to the AMI group(P>0.05).The mRNA expression levels of ANP and BNP in the Sham group,the Ticagrelor treatment group,and the Ticagrelor pretreatment+treatment group were lower than those in the AMI group[(1.22±0.34),(1.83±0.54),and(1.80±0.57)compared to(2.66±0.69);(1.08±0.24),(1.48±0.56),and(1.38±0.49)compared to(2.45±0.75)],with statistically significant differences(P<0.001).Conclusion Ticagrelor can improve left ventricular function in mice after AMI,enhance cardiac contractile function,reduce effectively ventricular dilation,and alleviate myocarditis and cardiac load.
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