Study on the Correlation Between"Blood Stasis"Level and BGP,TRACP5b in Postmenopausal Osteoporosis Patients
Objective To study the correlation between"blood stasis"levels[prostacyclin(PGI2),thromboxane A2(TXA2)],and bone metabolism indexes[bone glaprotein(BGP)and tartrate-resistant acid phosphatase 5b(TRACP5b)]in postmenopausal women with osteoporosis.Methods A total of 176 patients admitted to the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University from January to December 2022 were selected as the study objects.Among them,a total of 88 postmenopausal patients with secondary osteoporosis were used as the osteoporosis group,and 88 postmenopausal normal women without clinical manifestations of osteoporosis were used as the normal control group.Serum PGI2,TXA2,BGP,TRACP5b and other related indicators were detected in the 2 groups,and then the correlation between them was analyzed.Results TXA2 in osteoporosis group was(139.34±6.56)ng/L,higher than(112.61±6.91)ng/L in normal control group,PGI2 was(94.27±8.15)ng/L,lower than(153.73±8.77)ng/L in normal control group(P<0.05).BGP in osteoporosis group was lower than that in normal control group,TRACP5b was higher than that in normal control group(P<0.05).BGP was positively correlated with PGI2,but negatively correlated with TXA2.TRACP5b was positively correlated with TXA2,but negatively correlated with PGI2.Conclusion In patients with osteoporosis,the decreased level of osteogenic active molecule BGP and the increased level of osteoclastogenic active molecule TRACP5b are closely related to the decreased level of vasoactive factor PGI2 and increased level of TXA2.The pathological changes of local bone metabolism microcirculation caused by"blood stasis"caused by the decrease of vasodilator factor level and the increase of vasodilator factor level are related to the incidence of osteoporosis.
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