Study on the Correlation Between Serum Inflammatory Factor Level and Lung Cancer Patients With Pulmonary Infection
Objective To explore the relationship between patent cooperation treaty(PCT),C-reactive protein(CRP),recombinant high mobility group protein 1(HMGB1),white blood cell(WBC),and lung cancer patients with pulmonary infection,and provide reference for clinical treatment.Methods A total of 159 patients admitted to the Minzu Hospital of Guangxi Zhuang Autonomous Region from January 2021 to December 2022 were selected as the subjects.Among them,95 cases of lung cancer without lung infection were used as control group,and 64 cases of lung cancer with lung infection were used as observation group.According to the clinical pulmonary infection score(CPIS),the patients were divided into mild group(n=22),moderate group(n=21),and severe group(n=21).The distribution of pathogenic bacteria in lung cancer patients with pulmonary infection was analyzed,the levels of inflammatory factors and ventilation function of the two groups were compared,and the levels of inflammatory factors and ventilation function of patients with different degrees of pulmonary infection were analyzed,and the correlation was analyzed.Results A total of 69 strains of pathogenic bacteria were detected in sputum samples of 64 patients with lung cancer,including 18 Gram-positive bacteria,42 Gram-negative bacteria and 9 Fungi.The levels of CRP,PCT,HMGB1,WBC,peak inspiratory pressure(PIP),work of breath(WOB)and frequency response(Fres)in observation group were higher than those in control group,and dynamic pulmonary compliance(Cdyn)was lower than that in control group,the difference was statistically significant(P<0.05).Serum CRP,PCT,HMGB1,WBC,PIP,WOB and Fres in mild,moderate and severe groups were increased successively,and the difference was statistically significant(P<0.05).Cdyn in mild group,moderate group and severe group was decreased successively,the difference was statistically significant(P<0.05).Serum PCT and WBC levels were positively correlated with the degree of infection(r=0.363,0.382,P<0.05).Conclusion Gram-negative bacteria are the main pathogens in patients with lung cancer complicated with lung infection.Compared with patients with lung cancer,the levels of serum inflammatory factors are higher,and the indicators of ventilation function are worse,and the changes in their levels are related to the degree of infection.Clinical monitoring of relevant indicators can provide a reference for clinical diagnosis and treatment of lung cancer complicated with lung infection.
lung cancerlung infectioninflammatory factorsprocalcitoninC-reactive proteinrecombinant high mobility group protein 1white blood cell
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维普
