Expression Analysis of Serum CA19-9,CA72-4 and CEA Levels in Patients With Abnormal Pepsinogen and Gastrin 17 Levels During Physical Examination
Objective To study the expression levels analysis of carbohydrate antigen 19-9(CA19-9),carbohydrate antigen 72-4(CA72-4),and carcinoembryonic antigen(CEA)in the serum of individuals undergoing physical examination under abnormal serum levels of pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),gastrin 17(G-17)and pepsinogenⅠ/pepsinogenⅡ(PGR).Methods A total of 4 354 examinees who underwent physical examinations at the health management center,the 910th Hospital of the Joint Logistics Support Force of the People's Liberation Army of China from January 2021 to December 2023 were selected.They were divided into low-risk G-17(-)and PG(-)groups,high-risk G-17(+)or PG(+)groups,and high-risk G-17(+)and PG(+)groups for gastric cancer according to whether G-17,PGⅠ,PGⅡ and PGR were abnormal.The levels of PGⅠ,PGⅡ and G-17 in peripheral blood were detected by enzyme-linked immunosorbent assay(ELISA),and the levels of CA19-9,CA72-4 and CEA in peripheral blood were detected by chemiluminescence assay.Results The serum CA19-9 concentration in the low-risk G-17(-)and PG(-)groups for gastric cancer was 9.84(6.72,14.72)IU/mL,while the CA19-9 concentration in the high-risk G-17(+)or PG(+)groups for gastric cancer was 9.39(6.26,14.27)IU/mL,and the CA19-9 concentration in the high-risk G-17(+)and PG(+)groups for gastric cancer was 11.03(6.02,17.90)IU/mL,the difference was statistically significant(P<0.05).The serum CA72-4 levels in the high-risk G-17(+)and PG(+)groups for gastric cancer was 1.16(0.44,2.13)IU/mL,while serum CA72-4 levels in the low-risk G-17(-)and PG(-)groups for gastric cancer was 1.49(0.62,3.32)IU/mL,and serum CA72-4 levels in the high-risk G-17(+)or PG(+)groups for gastric cancer was 1.47(0.64,3.18)IU/mL,the difference was statistically significant(P<0.05).Conclusion When G-17(+)and(or)PG(+)were abnormal,the combined detection of serum levels of CA19-9 and CA72-4 and the comprehensive consideration of clinical symptoms could well reflect the stomach health status of the subjects,timely detection of stomach problems,active gastroscopy and treatment,if necessary,surgical treatment.
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