摘要
目的 探讨尿常规检测在甲状腺功能亢进症(简称甲亢)临床诊治中的价值.方法 选取 2021 年 1 月—2023 年6 月福建省漳州市医院诊治的 200 例甲亢患者作为研究组,以同期接受健康体检的 100 名健康自愿者作为对照组.均行尿常规检测和甲状腺激素测定,对比 2 组尿pH值、尿蛋白、尿酮体、尿胆红素、尿糖水平及血清游离三碘甲状腺原氨酸(free triiodothyronine,FT3)、游离甲状腺素(free tetraiodothyronine,FT4)及促甲状腺激素(thyroid stimulating hormone,TSH)水平,并分析两者相关性.结果 研究组尿pH值为(5.89±1.04),低于对照组的(6.55±0.42),而尿密度值、尿蛋白、尿酮体、尿胆红素、尿糖水平分别为(1.12±0.08)g/cm3、(175.45±22.52)mg/L、(0.74±0.12)mmol/L、(7.12±1.06)mg/L、(2.81±0.45)mmol/L,均高于对照组的(1.01±0.02)g/cm3、(146.25±20.14)mg/L、(0.41±0.20)mmol/L、(4.41±1.05)mg/L、(1.72±0.33)mmol/L,差异有统计学意义(P＜0.05).研究组血清 FT3、FT4 分别为(21.22±10.42)pmol/L、(49.74±18.62)pmol/L,高于对照组的(4.83±0.93)pmol/L、(13.25±1.81)pmol/L,TSH为(0.21±0.03)μIU/mL,低于对照组的(1.62±0.15)μIU/mL,差异有统计学意义(P＜0.05).Pearson相关分析显示,甲亢患者尿常规检查指标尿密度值、尿蛋白、尿酮体、尿胆红素、尿糖与FT3、FT4 呈正相关(P＜0.05),与TSH呈负相关(P＜0.05).结论 甲亢患者尿常规指标相比健康人群有显著变化,与甲状腺激素水平存在相关性,可作为甲亢诊治潜在辅助指标.
Abstract
Objective To explore the value of urine routine testing in the clinical diagnosis and treatment of hyperthyroidism(hyperthyroidism).Methods A total of 200 hyperthyroidism patients diagnosed and treated in Zhangzhou Municipal Hospital of Fujian Province from January 2021 to June 2023 were selected as the study group,and 100 healthy volunteers who underwent physical examination during the same period were selected as the control group.Urine routine detection and thyroid hormone determination were performed.Urinary pH value,urinary protein,urinary ketone body,urinary bilirubin,urinary sugar levels and serum free triiodothyronine(FT3),free tetraiodothyronine(FT4)and thyroid stimulating hormone(TSH)levels of the two groups were compared,and the correlation between the two groups was analyzed.Results The urine pH of the study group was(5.89±1.04),lower than(6.55±0.42)of the control group.The levels of urinary density,urinary protein,urinary ketone body,urinary bilirubin and urinary sugar were(1.12±0.08)g/cm3,(175.45±22.52)mg/L,(0.74±0.12)mmol/L,(7.12±1.06)mg/L,(2.81±0.45)mmol/L,respectively,which were higher than(1.01±0.02)g/cm3,(146.25±20.14)mg/L,(0.41±0.20)mmol/L,(4.41±1.05)mg/L,(1.72±0.33)mmol/L of the control group,the difference was statistically significant(P<0.05).Serum FT3 and FT4 in the study group were(21.22±10.42)pmol/L and(49.74±18.62)pmol/L,respectively,which were higher t h a n(4.83±0.93)p m o l/L and(13.25±1.81)pmol/L in the control group,and TSH was(0.21±0.03)μIU/mL,which was lower than(1.62±0.15)μIU/mL of control group,the difference was statistically significant(P<0.05).Pearson correlation analysis showed that urine density,urinary protein,urinary ketone body,urinary bilirubin and urinary sugar of patients with hyperthyroidism were positively correlated with FT3 and FT4(P<0.05),and negatively correlated with TSH(P<0.05).Conclusion Urinary routine indicators in patients with hyperthyroidism show significant changes compared to healthy individuals and are correlated with thyroid hormone levels.They can serve as potential auxiliary indicators for the diagnosis and treatment of hyperthyroidism.
维普
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