Study on the Predictive Value of Myocardial Injury Markers Combined With AECC for MACE in HHD Patients
Objective To explore the predictive value of myocardial injury markers combined with dynamic electrocardiography(AECC)for major adverse cardiac events(MACE)in patients with hypertensive heart disease(HHD).Methods A retrospective analysis of 88 HHD patients admitted to the First People's Hospital of Tianmen in Hubei Province from January 2020 to December 2023 was conducted.Patients were grouped according to whether they developed MACE within 1 year,and were divided into study group(with MACE,n=18)and control group(without MACE,n=70).The AECC results and levels of myocardial injury markers between two groups were compared.The receiver operating characteristic(ROC)curve was plotted.Results The incidence of fragmented QRS complexes(fQRS)in the study group was 66.67%,higher than 24.29%in the control group,the difference was statistically significant(P<0.05).The microvolt T-wave alternans(MTWA),creatine kinase-MB(CK-MB),cardiac troponin I(cTnI)and N-terminal pro-B-type natriuretic peptide(NT-proBNP)of the study group were(62.35±6.25)μV,(14.26±1.07)U/L,(101.25±5.36)ng/mL and(4 022.35±151.36)pg/mL,respectively.They were higher than(47.98±4.06)μV,(10.89±0.79)U/L,(75.36±2.16)ng/mL and(3 625.35±121.35)pg/mL in the control group,and the difference was statistically significant(P<0.05).The ROC curve shows that the area under the joint prediction ROC curve was the largest,with AUC=0.933(95%CI 0.879-0.986).The analysis of the overall model quality results shows that the maximum model value for the joint indicator was 0.88.Conclusion The use of AECC for real-time monitoring and analysis of MTWA and fQRS waves,combined with the detection of NT-proBNP,CK-MB,and cTnI biomarkers,has high sensitivity and practical efficacy in predicting MACE in HHD patients.It can more accurately evaluate the risk of MACE in clinical practice and provide important reference and guidance for clinical practice.
万方数据
维普
