Analysis of Fatty Liver Prevalence and Related Influencing Factors
Objective To explore the prevalence of fatty liver,to find the influencing factors and associations of fatty liver and provide scientific basis for the prevention of fatty liver.Methods A total of 9 666 healthy individuals who underwent physical examinations at physical examination center Physical Examination Center,Shanxi Province Fenyang Hospital from January to December 2022 were selected as the research subjects,general data such as gender and age of the physical examination population.Using the laboratory testing of total cholesterol(TC),total bilirubin(TBil),total protein(TP),γ-glutamyl transpeptidase(γ-GT),high-density lipoproteincholesterol(HDL-C),glutamic pyruvic transaminase(ALT),glutamic oxaloacetic transaminase(AST),direct bilirubin(DBIL),indirect bilirubin(IBIL),alkaline phosphatase(ACP),triacylglycerol(TG),low density lipoprotein cholesterol(LDL-C),creatinine(CRE),very low density lipoprotein cholesterol(VLDL),urea(UREA),glucose(GLU)and uric acid(UA)of the indicators.Bultrasound was used for abdominal examination of liver,bile,spleen and kidney.The epidemiological investigation data,physical examination data and laboratory examination data were double entered using EpiData3.1 software,and the database file was established.The data were converted into SPSS 22.0 data file by the t-test,χ2 test and logistic regression model of SPSS 22.0 statistical software.Results The prevalence of fatty liver was 44.7%,55.7%and 32.1%in men,which was higher than women(P<0.001),and the prevalence of fatty liver increased with age.Multivariate logistic regression analysis showed that:Gender,age,TP,γ-GT,ALT,AST,TC,TG,VLDL,LDL-C,HDL-C,GLU,and UA are closely related to the incidence of fatty liver,with OR values(95%CI)of 1.006(0.081-1.148),1.220(1.168-1.275),1.028(1.017-1.039),1.008(1.006-1.010),1.007(1.001-1.012),0.989(0.980-0.998),1.003(1.000-1.005),0.650(0.345-1.227),1.634(1.524-1.751),1.086(0.576-2.047),respectively.2.300(1.213-4.363),0.546(0.287-1.035),1.246(1.187-1.308),1.005(1.004-1.006).The elevation of age,TC,TP,γ-GT,ALT,AST,TG,LDL-C,VLDL,GLU,and UA indicators is a risk factor for the development of fatty liver,while the elevation of gender and HDL-C indicators is a protective factor for the development of fatty liver.AST/ALT,TBil,DBIL,IBIL,ACP,UREA,CRE are not associated with the onset of fatty liver,with OR values(95%CI)of 0.492(0.413-0.585),0.944(0.790-1.129),1.009(0.842-1.209),1.060(0.886-1.268),1.003(1.000-1.005),1.006(0.967-1.047),and 0.989(0.985-0.993),respectively.Conclusion The prevalence of fatty liver in this region,and the prevalence of fatty liver in women increased with the increase of age.In addition,elevations in age,TC,TP,γ-GT,ALT,AST,TG,LDL-C,VLDL,GLU and UA indicators were risk factors for the onset of fatty liver;gender and elevated HDL-C indicators were protective factors for the onset of fatty liver disease.
万方数据
维普
