首页|替格瑞洛联合阿托伐他汀治疗急性脑梗死的疗效及不良反应

替格瑞洛联合阿托伐他汀治疗急性脑梗死的疗效及不良反应

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目的 探讨替格瑞洛联合阿托伐他汀治疗急性脑梗死的疗效及不良反应。方法 选取日照市人民医院 2023 年 1-10 月收治的急性脑梗死患者 80 例,采取随机数字表法分为 2 组,各 40 例。对照组实施阿托伐他汀治疗,观察组加用替格瑞洛治疗。对 2 组疗效、神经缺损功能及日常生活能力进行对比,同时统计不良反应。结果 治疗前,2 组美国国立卫生研究院脑卒中量表(National Institutes of Health Stroke Scale,NIHSS)及日常生活能力量表(Barthel,BI)评分比较,差异无统计学意义(P>0。05)。2 组治疗后NIHSS评分低于治疗前,BI指数高于治疗前(P<0。05)。治疗后,观察组的NIHSS评分为(4。05±1。87)分,低于对照组的(7。80±2。14)分;BI指数分别为(63。25±11。04)分,高于对照组的(54。77±10。17)分(P<0。05)。观察组的临床总有效率为 95。00%,高于对照组的 80。00%(P<0。05)。结论 替格瑞洛联合阿托伐他汀治疗急性脑梗死可帮助改善患者的临床症状及体征,可改善神经功能及日常生活能力,未增加不良反应,保证治疗方面的安全性。
The Efficacy and Adverse Reactions of Ticagrelor Combined With Atorvastatin in the Treatment of Acute Cerebral Infarction
Objective To explore and analyze the efficacy and adverse reactions of ticagrelor combined with atorvastatin in the treatment of acute cerebral infarction.Methods A total of 80 patients who with the acute cerebral infarction were treated in the People's Hospital of Rizhao from January to October 2023 were selected,the patitens was taken the time table to ramdomly divided into the two groups,with 40 cases in each group.The control group was treated by the atorvastatin,and the observation group was treated by ticagrelor.The efficacy,nerve deficit function and daily living ability of the two groups were compared and adverse reactions were counted.Results Before treatment,there was no statistically significant difference between the two groups in the National Institutes of Health Stroke Scale(NIHSS)and Barthel Index(BI)scores(P>0.05).After treatment,the NIHSS score in both groups was lower than before treatment,and the BI index was higher than before treatment(P<0.05).After treatment,the NIHSS score of the observation group was(4.05±1.87)points,which was lower than that(7.80±2.14)points of the control group;The BI indices were(63.25±11.04)points,which were higher than(54.77±10.17)points of the control group(P<0.05).The total clinical effective rate of the observation group was 95.00%,which was higher than 80.00%of the control group(P<0.05).Conclusion The combination of ticagrelor and atorvastatin in the treatment of acute cerebral infarction can help to improve the clinical symptoms and signs of patients,and can significantly promote the improvement of neurological function and daily living ability,without increasing adverse effects,and ensure the safety of treatment.

ticagreloratorvastatinacute cerebral infarctionnerve functioncurative effectadverse reaction

迟娜娜、杨阳、武英、董庆林

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日照市人民医院急诊医学科,山东 日照 276800

替格瑞洛 阿托伐他汀 急性脑梗死 神经功能 疗效 不良反应

2024

中国卫生标准管理
《中国卫生标准管理》杂志社

中国卫生标准管理

影响因子:1.374
ISSN:1674-9316
年,卷(期):2024.15(17)