A Study on the Effects of Rifaximin on Inflammatory Factors and Gut Microbiota in Patients With Liver Cirrhosis and Ascites
Objective To Explore the effects of rifaximin on inflammatory factors and gut microbiota in patients with liver cirrhosis ascites.Methods A total of 112 patients with liver cirrhosis and ascites admitted to the department of gastroenterology at Jiaozhou Hospital,Dongfang Hospital Affiliated to Tongji University from January 2022 to June 2023 were selected as the study subjects and randomly divided into a control group and an observation group,with 56 patients in each group.The control group received routine treatment,while the observation group received"routine+rifampicin"treatment.Compare the inflammatory factors and gut microbiota of two groups of patients.Results From the inflammatory level,after treatment,interleukin-21(IL-21)、interleukin-22(IL-22)and transforming growth factor-β1(TGF-β1)values of(30.27±4.26)pg/mL,(31.22±4.18)pg/mL,and(3.14±1.02)pg/mL were significantly lower than those of the control group(41.02±4.85)pg/mL,(41.49±4.93)pg/mL,and(4.86±1.57)pg/mL,respectively(P<0.05).From the perspective of gut microbiota,after treatment,the observation group of patients had significantly higher levels of bifidobacteria and lactobacilli at(9.91±0.52)cfu/g and(7.92±0.33)cfu/g,respectively,compared to the control group at(8.76±0.48)cfu/g and(7.16±0.28)cfu/g(P<0.05).After treatment,the observation group of patients had significantly lower levels of(6.74±0.35)cfu/g and(7.45±0.46)cfu/g,respectively,compared to the control group at(7.44±0.41)cfu/g and(8.57±0.52)cfu/g(P<0.05).From the perspective of liver function,after treatment,the liver function levels of both groups of patients were significantly improved,and the improvement effect of the observation group was significantly better than that of the control group(P<0.05).Conclusion In the treatment of patients with liver cirrhosis ascites,the combination of conventional treatment and rifaximin treatment can effectively control the patient's inflammatory level,improve the intestinal microbiota environment,and enhance liver function.The treatment effect is significant,providing reference content for the formulation of standardized treatment standards for liver cirrhosis ascites.
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