Analysis of Changes and Clinical Significance of Serum PAF and Anti-CCD IgE Levels in Patients With Chronic Urticaria
Objective To analyze the changes and clinical significance of serum platelet activating factor(PAF)and anti-cross reactive carbohydrate determinants immunoglobulin E(anti-CCD IgE)levels in patients with chronic urticaria,in order to provide reference for clinical diagnosis,disease severity,and prognosis evaluation.Methods A total of 100 patients with chronic urticaria treated in Guangzhou Institute of Dermatology from May 2021 to May 2023 were selected and divided into mild group(n=41),moderate group(n=35)and severe group(n=24)according to urticaria activity score.Fasting venous blood was collected from the patients,and serum PAF levels were measured using enzyme-linked immunosorbent assay.Anti-CCD IgE and allergen specific immunoglobulin E(sIgE)were measured using dot immunoblotting.The serum PAF levels of chronic urticaria patients with different degrees of illness were compared,the correlation between serum PAF levels and urticaria activity score in patients with chronic urticaria were analyzed,and the anti-CCD IgE positive rate in patients with different clinical characteristics of chronic urticaria were compared.Results The serum PAF levels of patients in the moderate group and severe group were higher than those in the mild group,while the serum PAF levels of patients in the severe group were higher than those in the moderate group,the difference was statistically significant(P＜0.05).The Pearson correlation analysis results showed a positive correlation between serum PAF levels and urticaria activity score in patients with chronic urticaria(r=0.491,P＜0.001).The anti-CCD IgE positive rate in patients with age ≥ 45 years old,severe illness,and sIgE positive conditions was higher than that in patients with age＜45 years old,mild illness,and sIgE negative conditions,the difference was statistically significant(P＜0.05).Among anti-CCD IgE positive patients,the combination of dust mites(66.67％)had the highest allergen positivity,followed by cockroaches,crabs,and common ragweed,accounting for 55.56％,44.44％and 44.44％,respectively.Conclusion The serum PAF level in patients with chronic urticaria is closely related to their condition,and there is a certain relationship between anti-CCD IgE level and sIgE level.The positive expression of anti-CCD IgE in sIgE test may interfere with the results,and the impact of anti-CCD IgE should be considered when analyzing the test results.
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