Effects of Prehospital Administration of Different Doses of Epinephrine in Patients With Cardiac Arrest
Objective To explore the effect of different doses of epinephrine in prehospital emergency for cardiac arrest.Methods A total of 85 patients with cardiac arrest treated in the department of emergency,Dongguan Hengli Hospital from January 2020 to October 2023 were selected as the study objects,Which were grouped according to the different doses of epinephrine used,the control group(n=42)was treated with the conventional dose of epinephrine,and the observation group(n=43)was treated with the high dose of epinephrine.The resuscitation,rescue quality and adverse reactions of the two groups were compared.Results The success rate of resuscitation in the observation group was 93.02％,the recovery rate of autonomic circulation was 95.35％,the recovery rate of spontaneous respiration was 95.35％,and the survival rate after emergency was 97.67％,which were higher than 73.81％,76.19％,71.43％,73.81％in the control group,and the differences were statistically significant(P＜0.05).At admission,there was no significant difference in recombinant S100 calcium binding protein(S100),B-type urinary natriuretic peptide and serum procalcitonin between 2 groups(P＞0.05).2 h after first aid,the indexes of both groups decreased,S100 in observation group was(0.32±0.06)pg/L,B-type natriuretic peptide was(172.12±6.32)pg/mL,and serum procalcitonin was(23.51±4.28)ng/mL,which were lower than(0.57±0.11)pg/L,(203.14±52.24)pg/mL,(28.36±6.15)ng/mL in control group,and the difference was statistically significant(P＜0.05).The total incidence of adverse reactions in the observation group was 4.65％,lower than 21.43％in the control group,and the difference was statistically significant(P＜0.05).Conclusion The use of high-dose epinephrine can increase the resuscitation rate of patients with cardiac arrest,improve the autonomic circulation and autonomic respiration,and can rapidly improve the resuscitation effect of patients,with a high degree of safety,and is worthy of use in prehospital emergency.
different dosesepinephrinecardiac arrestprehospital emergencyadverse reactionsresuscitation success rate
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