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剖宫产史对不孕症患者人工授精助孕结局的影响

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目的 研究剖宫产史对人工授精助孕临床妊娠率的影响。方法 回顾性分析 2012 年 2 月—2022 年 6 月在厦门大学附属妇女儿童医院生殖医学科接受夫精人工授精(artificial insemination by husband,AIH)治疗的至少有 1 次活胎分娩史的不孕患者336例,共560个周期,其中瘢痕子宫组203个周期,阴道分娩组 357 个周期。比较 2 组年龄、身体质量指数(body mass index,BMI)、输卵管盆腔因素、内膜异位症占比、治疗方案及助孕结果等。结果 2组的年龄、高龄占比(>35岁)、不孕年限、输卵管盆腔因素、内膜异位症占比比较,差异无统计学意义(P>0。05)。瘢痕子宫组患者BMI为(22。30±3。27)kg/m2,高于阴道分娩组的(21。67±2。76)kg/m2(P<0。05)。瘢痕子宫组BMI>23 kg/m2 的比例为 36。9%,高于阴道分娩组的29。7%,差异无统计学意义(P=0。078)。瘢痕子宫组诱导排卵方案占比为 53。7%(109/203),高于经阴道分娩组的 44。3%(158/357),差异有统计学意义(P<0。05)。瘢痕子宫组临床妊娠率为 15。3%,阴道分娩组为 16。5%,差异无统计学意义(P=0。853)。结论 通过适当的干预与筛选,可以提高有剖宫产史妇女的宫腔内人工授精临床妊娠率。
The Influence of Cesarean Section History on the Outcome of Artificial Insemination Assisted Pregnancy in Infertile Patients
Objective To analysis the effect of history of cesarean section on the clinical pregnancy rate of artificial insemination.Methods A retrospective analysis was performed on 336 infertile patients with at least one live birth history who received artificial insemination by husband(AIH)treatment at the department of reproductive medicine,Women and Children's Hospital,School of Medicine,Xiamen University,from February 2012 to June 2022,with a total of 560 cycles,including 203 cycles in the cesarean section group and 357 cycles in the other group.Age,BMI,tubal and pelvic factors,history of endometriosis,treatment protocol and pregnancy result were compared in the two groups.Results There were no significant differences in age,senior age(>35 years old),infertility duration,tubal-pelvic factors and history of endometriosis between the two groups.Body mass index(BMI)in cesarean section group was significantly higher than that in vaginal delivery group,(22.30±3.27)kg/m2 and(21.67±2.76)kg/m2,respectively(P<0.05).The proportion of patient's BMI over 23 kg/m2 in cesarean section group was higher than that of the vaginal delivery group,36.9%and 29.7%,respectively,the difference was not statistically significant(P=0.078).The proportion of induced ovulation in cesarean section group was significant higher than that in vaginal delivery group(53.7%vs.44.3%,P<0.05.The clinical pregnancy rate of cesarean section group was 15.3%,and that of vaginal delivery group was 16.5%,the difference was not statistically significant(P=0.853).Conclusion Through appropriate intervention and screening,the clinical pregnancy rate of IUI in women with a history of cesarean section can be improved.

caesarean sectionvaginal deliveryartificial insemination by husbandclinical pregnancy rateovulation inductionbody weight index

邓冰冰、林津、龚秀芳、黄惠、李萍

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厦门大学附属妇女儿童医院(厦门市妇幼保健院) 生殖医学科,福建 厦门 361003

厦门市生殖与遗传 重点实验室,福建 厦门 361003

剖宫产史 阴道分娩 夫精人工授精 临床妊娠率 诱导排卵 身体质量指数

2024

中国卫生标准管理
《中国卫生标准管理》杂志社

中国卫生标准管理

影响因子:1.374
ISSN:1674-9316
年,卷(期):2024.15(19)