Clinical Study on the Correlation Between ADP-Induced Platelet Aggregation and Risk of Recurrence of Cerebral Infarction
Objective To explore the correlation between adenosine diphosphate(ADP)-induced platelet aggregation levels and recurrent stroke in patients with ischemic stroke taking clopidogrel,providing reference for clinical antiplatelet therapy.Methods This prospective cohort study included 120 patients with cerebral infarction admitted to Jieyang People's Hospital from July 2021 to June 2022,who received conventional therapy and antiplatelet therapy(clopidogrel 75 mg,once a day).The platelet aggregation rate 5 days after treatment was detected,and the patients were divided into 3 groups according to the maximum platelet aggregation rate,they were group A(>55%),group B(35%to 55%)and group C(<35%)accouting for 35 cases,46 cases and 39 cases.Health education was given to patients to improve treatment compliance and 1-year follow-up was conducted.The logistic regression was used to analyze the correlation between platelet aggregation rate and the risk of cerebral infarction recurrence.Results After 1 year of follow-up,ischemic stroke recurred in 8 patients in group A,3 patients in group B and 2 patients in group C,with recurrence rates of 22.9%,6.5%and 5.1%,respectively,with statistical significance(P<0.05).In group A,group B and group C,hemorrhagic stroke occurred in 1,2 and 3 patients,with bleeding rates of 2.9%,4.3%and 7.7%,respectively,with no statistical significance(P>0.05).The logistic regression analysis showed that the maximum platelet aggregation rate was an independent risk factor for cerebral infarction recurrence(OR=3.320,P<0.05).Conclusion After ischemic stroke patients take clopidogrel,the level of ADP-induced platelet aggregation is positively correlated with the risk of recurrent stroke.The higher the platelet aggregation rate,the greater the risk of recurrent stroke.Platelet aggregation rate can serve as an indicator to assess the efficacy of clopidogrel antiplatelet therapy,providing a basis for personalized clinical treatment.
万方数据
维普
