Effects of Adjuvant Therapy With Bifidobacterium Triple Viable Tablets on Gastrointestinal Hormone Levels in Children Infected With Rotavirus Enteritis
Objective To investigate the effect of probiotics adjuvant therapy in children with bifidobacterium triple viable tablet.Methods A total of 80 children with rotavirus infection enteritis admitted to Shaowu Municiple Hospital from May 2022 to August 2023 were selected,and divide them into a control group(conventional intervention,n=40)and an observation group(treatment with triple active bifidobacteria tablets,n=40)according to a random number table method.The clinical symptom relief time,immune function,gastrointestinal hormones,and intestinal mucosal permeability between the two groups were compared.Results The time of antidiarrheal,antiemetic,antipyretic and stool returning to normal in the observation group was lower than control group(P<0.05).After 5 days of treatment,immunoglobulin G,immunoglobulin M and CD4+/CD8+ratio of the observation group were(11.31±2.17)g/L,(16.04±5.21)g/L and(0.88±0.21),respectively,which were higher than the control group(9.22±1.35)g/L、(11.93±4.16)g/L、(0.65±0.22)(P<0.05).After 5 days of treatment,gastrin,motilin and vasoactive intestinal peptide of the observation group were(76.32±10.29)ng/L,(195.72±20.37)ng/L and(50.32±8.28)pg/mL,respectively,which were lower than the control group(83.68±15.57)ng/L、(231.66±23.71)ng/L、(56.27±9.35)pg/mL(P<0.05).After 5 days of treatment,the levels of advanced glycation end products and diamine oxidase of the observation group were(200.51±23.86)ng/L and(0.77±0.41)U/L,respectively,which were lower than those in the control group(255.68±28.23)ng/L、(1.63±0.38)U/L(P<0.05).Conclusion The adjuvant therapy of bifidobacterium triple live tablets can enhance the immune function of children,promote the recovery of gastrointestinal hormone levels,reduce intestinal permeability,and help shorten the recovery time of symptoms such as antiemesis and fever.
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