Objective To explore the clinical effects of low-dosage prednisone acetate in the treatment of subacute thyroiditis,providing reference on the planning of treatment schemes.Methods A total of 86 patients with subacute thyroiditis at Yancheng No.1 People's Hospital,Jiangsu Province from January 2020 to October 2023 were selected and divided into a control group(43 patients with conventional dose of prednisone acetate)and an observation group(43 patients with low-dose prednisone acetate)based on different treatment doses of prednisone acetate.The improvement of clinical symptoms and signs,thyroid function and erythrocyte sedimentation rate,clinical efficacy,and adverse reactions between two groups of patients were compared.Results The comparison of fever resolution time,thyroid pain resolution time,and thyroid tenderness resolution time between the two groups showed no statistically significant difference(P>0.05).The serum free triiodothyronine(FT3)levels in the control group and observation group patients after treatment were(2.57±0.74)pg/mL and(2.63±0.67)pg/mL,respectively;The serum levels of free thyroxine(FT4)were(1.43±0.48)ng/dL and(1.58±0.31)ng/dL,respectively.The serum levels of thyroid stimulating hormone(TSH)were(0.49±0.11)uIU/mL and(0.46±0.09)uIU/mL.The erythrocyte sedimentation rate was(16.28±5.19)mm/h and(16.43±5.21)mm/h,with no statistically significant difference(P>0.05).The total effective rate of the observation group was 90.70%,while the control group was 86.05%,with no statistically significant difference(P>0.05).The incidence of adverse reactions in the observation group was 6.98%,which was lower than 23.26%of the control group,and the difference was statistically significant(P<0.05).Conclusion Both of the standard-dosage and low-dosage prednisone acetate can achieve the favorable treatment effects,reduce the clinical symptoms and improve the patient's thyroid function.However,the low-dosage prednisone acetate can further reduce the adverse reactions risks for subacute thyroiditis patients.
维普
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