Research Progress on the Long-Term Effects of Metformin on the Offspring of Pregnant Women With Hyperglycemia During Pregnancy
Hyperglycemia in pregnancy refers to different levels of glucose metabolism disorders occurring before or during pregnancy,which seriously affect the outcome of mother and child.In recent years,the incidence of hyperglycemia during pregnancy has been increasing,and pregnant women with hyperglycemia during pregnancy are usually treated with insulin and oral drugs when diet and exercise management are not well controlled.As an oral hypoglycemic drug,metformin can not only reduce the blood sugar of pregnant women,but also reduce the incidence of adverse events such as neonatal hypoglycemia and macrosomia,and effectively control the weight gain of pregnant women during pregnancy.Metformin therapy is safe for the mother,but unlike insulin therapy,metformin is able to cross the placenta and enter the fetus.Therefore,there are still concerns about the effect of metformin therapy on the long-term prognosis of the fetus.At present,the extent of the long-term growth and development of maternal offspring affected by metformin treatment is still unclear at home and abroad.This review summarizes the mechanism of action of metformin and the long-term growth and development of offspring.The results of this study provide references for the later development of clinical guidelines for hyperglycemia in pregnancy.
metforminhyperglycemia in pregnancylong-term effectsmaternal and infant outcomesfetal developmentchildgrowth and development
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