Correlation Analysis of Serum 25-Hydroxy-Vitamin D and Insulin Resistance in Gestational Diabetes Mellitus
Objective To investigate the correlation between serum 25-hydroxy-vitamin D (25-OH-VD) level and insulin resistance in patients with gestational diabetes mellitus. Methods A total of 65 pregnant women with gestational diabetes mellitus admitted to Zibo Maternal and Child Health Hospital from March 2021 to March 2023 were selected as the observation group,and 65 healthy pregnant women admitted to the hospital during the same period were selected as the control group. Fasting venous blood was collected to detect serum 25-OH-VD,blood glucose,and insulin index,and the levels of each index were compared between the two groups. Pearson correlation analysis was used to analyze the relationship between 25-OH-VD and blood glucose and insulin index. Multivariate logistic regression analysis was used to analyze the independent risk factors for gestational diabetes mellitus. Results The levels of glycosylated hemoglobin (HbAlc),fasting blood glucose (FBG),2 hour postprandial blood glucose (2 hPBG),fasting insulin (FINS) and homeostasis model assessment-insulin resistance index (Homa-IR) in observation group were higher than those in control group,while the levels of homeostasismodel assessment β cell function (Homa-β) and 25-OH-VD in observation group were lower than those in control group (P<0.05). The nutritional status of vitamin D in the observation group was 36.92％ deficient,58.46％ insufficient and 4.62％ adequate,while that in the control group was 15.38％ deficient,53.85％ insufficient and 30.77％ adequate,the difference was statistically significant (P<0.05). 25-OH-VD was negatively correlated with HbAlc,FBG,2 hPBG,FINS and Homa-IR (P<0.05),and positively correlated with Homa-β (P<0.05). 25-OH-VD deficiency was an independent risk factor for gestational diabetes mellitus (P<0.05). Conclusion Serum 25-OH-VD is closely related to blood glucose and insulin resistance in patients with gestational diabetes mellitus,and deficiency of 25-OH-VD is an independent risk factor for gestational diabetes mellitus,which has high research value.
万方数据
维普
