Meta-Analysis of the Diagnostic Value of Ovarian Cancer by YKL-40 Expression in Ovarian Cancer Tissues
Objective The diagnostic value of ovarian cancer by YKL-40 expression in ovarian cancer tissues was evaluated by Meta-analysis. Methods Relevant literatures on the expression of YKL-40 in ovarian cancer tissue for diagnosis of ovarian cancer were searched in foreign and Chinese databases.The search period was from the establishment of the database to June 2022. According to defined inclusion criteria,the literature was selected and the data were extracted. Stata 16.0 software was used to analyze the diagnostic efficacy of tissue YKL-40 in diagnosing ovarian cancer. Results Eleven papers with 1962 patients,including 974 ovarian cancer and 988 non-ovarian cancer patients,were finally included. The sensitivity(Sen) of tissue YKL-40 for diagnosing ovarian cancer was 0.75 (95％CI 0.70-0.79),the specificity (Spe) was 0.75 (95％CI 0.64-0.84),the positive likelihood ratio (PLR) was 3.00 (95％CI 2.10-4.40),the negative likelihood ratio (NLR) was 0.33 (95％CI 0.27-0.41),the diagnosis odds ratios (DOR) of 9.00 (95％CI 5.00-16.00),and an summary receiver operating characteristic curves (SROC) area under curve (AUC) was 0.79 (95％CI 0.76-0.83). Conclusion The detection of YKL-40 expression in ovarian cancer tissues is of high value for the diagnosis of ovarian cancer.
万方数据
维普
