目的 分析联合检测D-二聚体、白细胞介素-6(interleukin-6，IL-6)及纤维蛋白原(fibrinogen，FIB)诊断急性胰腺炎的价值。方法 回顾性分析2021年1月—2023年9月厦门大学附属中山医院救治的164例急性胰腺炎患者。根据急性胰腺炎病情的严重程度进行分组，即轻症急性胰腺炎组(n=67)、中度重症急性胰腺炎组(n=47)、重症急性胰腺炎组(n=50);同时选择同期200名健康者设为对照组。所有患者均于入院48 h内测定D-二聚体、IL-6、FIB水平，并进行对比;同时阐明D-二聚体、IL-6、FIB单一检测及联合检测对诊断急性胰腺炎的临床意义与价值。结果 4组D-二聚体、IL-6、FIB水平比较，差异有统计学意义(P<0。05)。D-二聚体、IL-6、FIB水平均与急性胰腺炎病情严重程度呈正相关(P<0。05)。D-二聚体的曲线下面积(area under curve，AUC)、敏感度、特异度分别为0。941、86。57％、99。00％;IL-6的AUC、敏感度、特异度分别为0。844、79。10％、98。50％;FIB的AUC、敏感度、特异度分别为0。789、68。66％、81。00％;联合检测的AUC、敏感度、特异度分别为0。974、92。54％、93。00％。结论 D-二聚体、IL-6、FIB均可用于急性胰腺炎的诊断中，且上述指标水平的变化与急性胰腺炎病情具有相关性，同时联合检测更有助于减少漏诊、误诊的发生。
Value Analysis of Combined Detection of D-Dimer,IL-6 and FIB in Diagnosis of Acute Pancreatitis
Objective To analyze the value of combined detection of D-dimer,interleukin-6 (IL-6) and fibrinogen (FIB) in diagnosis of acute pancreatitis. Methods A retrospective analysis was performed on 164 patients with acute pancreatitis treated in Zhongshan Hospital Xiamen University from January 2021 to September 2023. Acute pancreatitis was grouped according to the severity of the disease,namely mild acute pancreatitis group (n=67),moderate severe acute pancreatitis group (n=47) and severe acute pancreatitis group (n=50). At the same time,200 healthy subjects were selected as control group. The levels of D-dimer,IL-6 and FIB in all patients were measured within 48 h after admission and compared,and the clinical significance and value of single and combined detection of D-dimer,IL-6 and FIB in the diagnosis of acute pancreatitis were clarified. Results The levels of D-dimer,IL-6 and FIB in 4 groups were compared,and the differences were statistically significant (P<0.05). D-dimer,IL-6 and FIB levels were positively correlated with the severity of acute pancreatitis (P<0.05). The area under curve (AUC),sensitivity and specificity of D-dimer were 0.941,86.57％ and 99.00％,respectively. The AUC,sensitivity and specificity of IL-6 were 0.844,79.10％ and 98.50％,respectively. The AUC,sensitivity and specificity of FIB were 0.789,68.66％ and 81.00％,respectively. AUC,sensitivity and specificity of combined detection were 0.974,92.54％ and 93.00％,respectively. Conclusion D-dimer,IL-6 and FIB can all be used in the diagnosis of acute pancreatitis,and the changes of the above indexes are correlated with the condition of acute pancreatitis,and the combined detection is more helpful to reduce the occurrence of missed diagnosis and misdiagnosis.
combined detectionD-dimerinterleukin-6fibrinogenacute pancreatitisdiagnostic value
万方数据
维普
