Application Effect of Early Postoperative Enteral Nutrition Therapy in Laparoscopic Radical Gastrectomy of Gastric Cancer
Objective To investigate the application effect of early postoperative enteral nutrition therapy in laparoscopic radical gastrectomy of gastric cancer. Methods A total of 100 patients with laparoscopic radical gastrectomy treated in People's Hospital of Ningxia Hui Autonomous Region from 2020 to 2023 were randomly divided into control group and observation group,50 cases in each group. The control group received intravenous nutrition support treatment,and the observation group received enteral nutrition treatment 24 h after surgery. The postoperative recovery,nutritional indexes[prognostic nutritional index (PNI),white blood cell count,total protein,albumin,prealbumin,transferrin],immune function indexes[immunoglobulin G (IgG),immunoglobulin A (IgA),immunoglobulin M (IgM),CD4+T lymphocyte (CD4+),CD8+T lymphocyte (CD8+),CD4+T lymphocyte/CD8+T lymphocyte (CD4+/CD8+) ratio],gastrointestinal function indexes[gastrin (GAS),motilin (MTL),growth hormone releasing peptide (Ghrelin),somatostatin (SS),cholecystokinin (CCK)]and gastrointestinal complications were compared between the two groups. Results In the observation group,the time of postoperative anal exhaust,the time of indwelling gastric tube,the time of indwelling drain,the time of starting liquid feeding,the time of ECG monitoring and the time of postoperative hospitalization were (3.63±0.35) d,(4.91±0.47) d,(6.70±0.68) d,(5.78±0.56) d,(2.71±0.25) d,(9.69±0.94) d,which were shorter than (4.12±0.39) d,(5.53±0.52) d,(7.85±0.72) d,(6.59±0.63) d,(3.34±0.32) d,(10.97±1.02) d in the control group (P<0.05). Five days after surgery,the levels of white blood cell count,prealbumin,Ghrelin and CCK in observation group were lower than those in control group,while the levels of PNI index,total protein,albumin,transferrin,IgG,IgA,IgM,CD4+,CD8+,CD4+/CD8+,GAS,MTL and SS in observation group were higher than those in control group (P<0.05). The total incidence of gastrointestinal complications in the observation group was 4.00％,lower than 18.00％ in the control group (P<0.05). Conclusion The application of early postoperative enteral nutrition in the treatment of laparoscopic radical gastrectomy for gastric cancer can accelerate postoperative recovery,improve body nutrition,immune function and gastrointestinal function,and reduce postoperative complications.
postoperativeenteral nutritionlaparoscopic radical gastrectomynutritional indeximmune functiongastrointestinal function
万方数据
维普
