Current Situation Investigation of Diarrhea Occurrence and Study of Influencing Factors in Patients Treated With HSCT
Objective To analyze the influencing factors of diarrhea occurrence in patients with hematopoietic stem cell transplantation (HSCT),and to provide guidance for clinical prevention. Methods A total of 90 patients with HSCT in the First Affiliated Hospital of Xiamen University were retrospectively analyzed from January 2022 to December 2023. According to whether diarrhea occurred during treatment,the patients were divided into 60 cases in diarrhea group and 30 cases in normal group. The relationship between diarrhea occurrence and general data (gender,age,education level,occupation,marital status,primary disease),transplant status (number,type,and time of transplantation),whether complications occurred,exercise self-efficacy,anxiety,depression,social support,and fatigue score were analyzed. Multivariate logistic regression model was used to analyze the risk factors of diarrhea. Results Among the 90 patients with HSCT,60 patients had diarrhea,accounting for 66.67％. The transplantation number,transplant type,transplantation time,presence or absence of complications and exercise self-efficacy were the single factors affecting the occurrence of diarrhea in HSCT patients (P<0.05). Multivariate logistic regression analysis showed that transplantation type being non autologous (OR=1.571,95％CI 1.011-2.442,P=0.045) was an independent risk factor for diarrhea in HSCT patients,and the number of one transplant (OR=0.950,95％CI 0.923-0.979,P<0.001),short transplantation time (OR=0.742,95％CI 0.638-0.863,P<0.001),and absence of complications (OR=0.909,95％CI 0.842-0.982,P=0.015) were protective factors. Conclusion Transplantation type being non autologous is an independent risk factor for increasing the risk of diarrhea in HSCT patients,and the number of one transplant,short transplantation time and absence of complications are protective factors for reducing the risk of diarrhea in HSCT patients. It is necessary to take relevant measures in advance to prevent the occurrence of HSCT treatment-related diarrhea.
万方数据
维普
