Effects of Etomidate Combined With Different Doses of Propofol on the Treatment of Major Depressive Disorder With MECT
Objective To analyze the effects of etomidate combined with different doses of propofol on patients with major depressive disorder treated with modified electro-convulsive therapy (MECT). Methods A retrospective analysis was performed for 111 patients with major depressive disorder who received MECT treatment at Fuzhou Second General Hospital Neuropsychiatric Prevention and Treatment Institute from January 2022 to March 2023. They were divided into group A,group B and group C according to the dosage of propofol,37 cases in each group. Group A received intravenous injection of 0.1 mg/kg etomidate+1.0 mg/kg propofol,group B received intravenous injection of 0.1 mg/kg etomidate+1.5 mg/kg propofol,and group C received intravenous injection of 0.1 mg/kg etomidate+2.0 mg/kg propofol. The anesthesia effects and safety of the three groups were compared. Results At T0 and T3,there was no significant difference in heart rate (HR),systolic blood pressure (SBP),diastolic blood pressure (DBP) and oxygen saturation of blood (SpO2) levels among three groups (P>0.05). At T1 and T2,the levels of HR,SBP,DBP in three groups were compared,and the differences were statistically significant (P<0.05). The total incidence of agitation was 25.50％ in group A,16.50％ in group B and 13.50％ in group C,the difference was statistically significant (P<0.05). The total incidence of agitation in groups B and C was lower than that in group A,the difference was statistically significant (P<0.05). The duration of agitation was (6.14±1.19) min in group A,(4.25±1.27) min in group B and (4.20±1.24) min in group C,and the difference between the three groups was statistically significant (P<0.05). The duration of agitation in groups B and C was shorter than that in group A,and the difference was statistically significant (P<0.05). The seizure time of EEG epileptic waves of group A and group B was longer than that of group C,respiratory depression was lower than that of group C,and consciousness recovery time was shorter than that of group C,the difference was statistically significant (P<0.05). There was no statistical significance in seizure time of EEG epileptic waves,respiratory depression and consciousness recovery time between group A and group B (P>0.05) There was no significant difference in the total incidence of adverse reactions among the three groups (P>0.05). Conclusion The use of 0.1 mg/kg etomidate combined with 1.5 mg/kg propofol in patients with severe depression undergoing MECT is more stable in terms of vital signs,and can ensure the safety of treatment and promote postoperative recovery.
万方数据
维普
