Evaluation Value of Serum 25 Hydroxyvitamin D and Systemic Immune-Inflammation Index in the Severity and Prognosis of the Patients With Dilated Cardiomyopathy
Objective To investigate the levels of serum 25 hydroxyvitamin D[25(OH)D]and systemic immune-inflammation index (SII) in the patients with dilated cardiomyopathy(DCM),and analysis the evaluation value of 25 (OH) D and SII in the severity and prognosis of DCM.Methods A total of 104 DCM patients admitted to the department of cardiology,the Second Hospital of Sanming from June 2020 to June 2023 were included as the DCM group,and 104 healthy examinees were included as the control group.The differences in biochemical indicators,blood pressure,cardiac function indicators,N-terminal B-type natriuretic peptide precursor,25 (OH) D,and SII between two groups were compared.According to the classification of heart function,DCM was divided into heart function level Ⅱ,Ⅲ and Ⅳ.According to Lee's heart failure score,DCM was divided into mild heart failure,moderate heart failure,and severe heart failure groups,and the differences in 25 (OH) D and SII between the groups were compared.Pearson method was used to analyze the correlation between 25 (OH) D,SII and cardiac function indicators.The evaluation value of 25 (OH) D and SII in assessing the severity of DCM were analyzed by the working characteristic curves of subjects.Results In the DCM group,the levels of triglyceride (TG) was (1.77±0.37) mmol/L,low density lipoprotein cholesterol,LDL-C) (2.84±0.81) mmol/L,systolic blood pressure (124.23±8.87) mmHg,diastolic blood pressure (78.44±8.28) mmHg,N-terminal B-type brain natriuretic peptide precursor (NT-proBNP) (1509.55±444.53) pg/Ml,SII(897.54±107.89) ×109/L,left atrial end-systolic diameter,LAD) (45.92±7.17) mm,left ventricular end-diastolic diameter (LVEDD) (64.53±7.10) mm,left ventricular end-systolic volume (LVESV) (57.23±4.50) Ml,left ventricular end-diastolic volume (LVEDV) (87.85±9.38) Ml,which were higher than the levels of (1.63±0.38) mmol/L,(2.53±0.56) mmol/L,(120.39±7.71) mmHg,(74.50±7.60) mmHg,(78.88±10.33) pg/Ml,(309.66±59.69) ×109/L,(28.02±3.53) mm,(44.47±2.59) mm,(31.78±3.80) Ml,(63.50±4.43) Ml in the control group,the differences were statistically significant (P<0.01).The albumin (37.30±3.81) g/L,25 (OH) D (28.96±4.31) ng/Ml,and LVEF (33.97±5.42)％ in the DCM group were all lower than those of (43.10±2.93) g/L,(66.79±5.33) ng/Ml,and (66.01±6.19)％ in the control group,the differences were statistically significant (P<0.001).With the increase of cardiac function grade and Lee's heart failure score,serum 25 (OH) D was gradually decreased and SII was gradually increased in DCM patients,with statistical significance (P<0.001).Pearson correlation analysis showed that serum 25(OH)D was negatively correlated with Lee's heart failure score (r=-0.612,P<0.001),NT-proBNP (r=-0.688,P<0.001),LVESV (r=-0.586,P=0.006) and LVEDV (r=-0.649,P<0.001),but positively correlated with LVEF (r=0.704,P<0.001).SII was positively correlated with Lee's heart failure score(r=0.721,P<0.001),NT-proBNP (r=0.662,P<0.001),LVESV(r=0.674,P<0.001) and LVEDV (r=0.733,P<0.001),but negatively correlated with LVEF (r=-0.589,P=0.002).ROC curve analysis showed that the sensitivity of 25(OH)D and SII to predict the severity of DCM were 80.13％ and 76.51％,the specificity was 78.44％ and 86.15％,and the area under the curve were 0.842 and 0.794.Conclusion The levels of SII and 25(OH)D are correlated with DCM disease,and have important predictive value for DCM disease severity and prognosis.
万方数据
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